Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/EHP2777
Personal Author:
Jackson-Browne, Medina S.; Papandonatos, George D.; Chen, Aimin; Calafat, Antonia M.; Yolton, Kimberly; ... More +
Jackson-Browne, Medina S.; Papandonatos, George D.; Chen, Aimin; Calafat, Antonia M.; Yolton, Kimberly; Lanphear, Bruce P.; Braun, Joseph M.; Less -
Description:
Background: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. Objective: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. Methods: We quantified triclosan in urine samples from mother–child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan–IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods. Results: Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [−4.5 points (95% CI: −7.0, −2.0)]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan–visit interaction p≤0.04). Conclusion: Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children’s cognitive test scores at 8 y of age in this cohort of U.S. children. https://doi.org/10.1289/EHP2777
Subject:
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Research

Source:
Environ Health Perspect. 126(5).;
Pubmed ID:
29727133
Pubmed Central ID:
PMC6072011
Document Type:
Journal Article;
Funding:
P01 ES011261/ES/NIEHS NIH HHS/United States; R01 ES014575/ES/NIEHS NIH HHS/United States; R01 ES020349/ES/NIEHS NIH HHS/United States; R01 ES024381/ES/NIEHS NIH HHS/United States;
P01 ES011261/ES/NIEHS NIH HHS/United States; R01 ES014575/ES/NIEHS NIH HHS/United States; R01 ES020349/ES/NIEHS NIH HHS/United States; R01 ES024381/ES/NIEHS NIH HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1d0466266dcec23be47653fb9a3f664bf1d3f880bcb86485e85c0b228a8557c6
File Type:

Supporting Files

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