Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Jackson-Browne, Medina S. ; Papandonatos, George D. ; Chen, Aimin ; Calafat, Antonia M. ; Yolton, Kimberly ; Lanphear, Bruce P. ; Braun, Joseph M.
• Description:
  Background:
  
  Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment.
  
  Objective:
  
  Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study.
  
  Methods:
  
  We quantified triclosan in urine samples from mother–child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan–IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods.
  
  Results:
  
  Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [−4.5 points (95% CI: −7.0, −2.0)]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan–visit interaction p≤0.04).
  
  Conclusion:
  
  Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children’s cognitive test scores at 8 y of age in this cohort of U.S. children. https://doi.org/10.1289/EHP2777
  
  
• Subjects:
  Research
• Source:
  Environ Health Perspect. 126(5).
• Pubmed ID:
  29727133
• Pubmed Central ID:
  PMC6072011
• Document Type:
  Journal Article
• Funding:
  P01 ES011261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States
• Volume:
  126
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1d0466266dcec23be47653fb9a3f664bf1d3f880bcb86485e85c0b228a8557c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/58263/cdc_58263_DS1.pdf
• File Type:
  [PDF - 464.46 KB ]