Details:

Alternative Title:
Sci Rep
Personal Author:
Pegalajar-Jurado, Adoracion ; Fitzgerald, Bryna L. ; Islam, M. Nurul ; Belisle, John T. ; Wormser, Gary P. ; ... More +
Pegalajar-Jurado, Adoracion ; Fitzgerald, Bryna L. ; Islam, M. Nurul ; Belisle, John T. ; Wormser, Gary P. ; Waller, Kathlene S. ; Ashton, Laura V. ; Webb, Kristofor J. ; Delorey, Mark J. ; Clark, Rebecca J. ; Molins, Claudia R. ; Less -
Description:
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. In this study, metabolomics approaches were applied to evaluate small molecule metabolites in urine from patients with ELD (n = 14), infectious mononucleosis (n = 14) and healthy controls (n = 14). Metabolic biosignatures for ELD versus healthy controls and ELD versus infectious mononucleosis were generated using untargeted metabolomics. Pathway analyses and metabolite identification revealed the dysregulation of several metabolic processes in ELD as compared to healthy controls or mononucleosis, including metabolism of tryptophan. Linear discriminant analyses demonstrated that individual metabolic biosignatures can correctly discriminate ELD from the other patient groups with accuracies of 71 to 100%. These data provide proof-of-concept for use of urine metabolites as biomarkers for diagnostic classification of ELD.
Subject:
[+]
Article

Source:
Sci Rep. 8.
Pubmed ID:
30111850
Pubmed Central ID:
PMC6093930
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e43ef4bbe6fde2adc9a97987e34be8e42ea115574783cbcac57afa0a7a1eefd7
File Type:

Supporting Files

• 	41598_2018_29713_Fig5_HTML.gif	gif
  	41598_2018_29713_Fig5_HTML.jpg	jpeg
  	41598_2018_29713_MOESM1_ESM.docx	docx
  	41598_2018_29713_MOESM2_ESM.xlsx	xlsx
  	41598_2018_Article_29713.nxml	xml
  	41598_2018_29713_Fig1_HTML.gif	gif
  	41598_2018_29713_Fig1_HTML.jpg	jpeg
  	41598_2018_29713_Fig2_HTML.gif	gif
  	41598_2018_29713_Fig2_HTML.jpg	jpeg
  	41598_2018_29713_Fig3_HTML.gif	gif
  	41598_2018_29713_Fig3_HTML.jpg	jpeg
  	41598_2018_29713_Fig4_HTML.gif	gif
  	41598_2018_29713_Fig4_HTML.jpg	jpeg

More +