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Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study
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September 2018
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Source: Pancreas. 47(8):958-966
[PDF-192.86 KB]
Details:
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Alternative Title:Pancreas
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Personal Author:
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Description:Objectives
Pancreatic cancer continues to carry a poor prognosis with survival rates that have had minimal improvement over the past four decades. We report a population-based, comprehensive analysis of long-term survivors of pancreatic adenocarcinoma diagnosed in the diverse population of California.
Methods
Data from the California Cancer Registry were used to evaluate long-term survival. A total of 70,442 patients diagnosed with pancreatic adenocarcinoma between 1988 and 2009 were identified. Logistic regression was used to identify factors associated with achieving five-year survival.
Results
The overall five-year survival was 2.5%, with minimal incremental improvements throughout the three decades. Age, stage, degree of differentiation, and surgical resection were associated with five-year survival. Furthermore, younger age and receiving care at a National Cancer Institute-designated cancer center were similarly correlated with five-year survival regardless of surgical intervention. Additionally, we identified stage, differentiation, and adjuvant chemotherapy as significant factors for long-term survival in surgically resected patients. In the unresectable patients, Asian/Pacific Islanders and Hispanics were significantly more likely to reach the five-year milestone than non-Hispanic Whites.
Conclusions
Although pancreatic cancer mortality remains high, our study highlights baseline characteristics, treatment, biological factors and ethnicity that are associated with long-term survival. These findings may serve as a springboard for further investigation.
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Pubmed ID:30074526
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Pubmed Central ID:PMC6095724
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Volume:47
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Issue:8
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