Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Publisher's site:
http://dx.doi.org/10.15585/mmwr.mm6730a2
Personal Author:
El Zahran, Tharwat ; Schier, Joshua ; Glidden, Emily ; Kieszak, Stephanie ; Law, Royal ; ... More +
El Zahran, Tharwat ; Schier, Joshua ; Glidden, Emily ; Kieszak, Stephanie ; Law, Royal ; Bottei, Edward ; Aaron, Cynthia ; King, Andrew ; Chang, Arthur Less -
Description:
Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used as an antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine is not approved by the Food and Drug Administration (FDA) for medical use and is an unscheduled pharmaceutical agent* (1). Animal and human studies show that tianeptine is an opioid receptor agonist (2). Several case studies have reported severe Adverse Effects and even death from recreational abuse of tianeptine (3-5). To characterize tianeptine exposures in the United States, CDC analyzed all exposure calls related to tianeptine reported by poison control centers to the National Poison Data System (NPDS)| during 2000-2017. Tianeptine exposure calls, including those for intentional abuse or misuse, increased across the United States during 2014-2017, suggTesting a possible emerging public health risk. Most tianeptine exposures occurred among persons aged 21-40 years and resulted in moderate outcomes. Neurologic, cardiovascular, and gastrointestinal signs and symptoms were the most commonly reported health effects, with some effects mimicking opioid toxicity. A substantial number of tianeptine exposure calls also reported clinical effects of withdrawal. Among 83 tianeptine exposures with noted coexposures, the most commonly reported coexposures were to phenibut, ethanol, benzodiazepines, and opioids.
Subjects:
[+]
Adolescent Adult Adverse Drug Reaction Reporting Systems Aged Aged, 80 And Over Child Child, Preschool Drug-Related Side Effects And Adverse Reactions Environmental Exposure Female Full Report Humans Infant Male Middle Aged Poison Control Centers Thiazepines Young Adult
Source:
MMWR Morb Mortal Wkly Rep. 67(30):815-818.
Pubmed ID:
30070980
Pubmed Central ID:
PMC6072055
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:13cbd4fda81cda4737c4747f4d7c7f35cf32e4eb2df0dcc781d25f0f2d90a917
Download URL:
https://stacks.cdc.gov/view/cdc/58128/cdc_58128_DS1.pdf
File Type:

Supporting Files

• 	mm6730a2-F.gif	gif
  	mm6730a2-F.jpg	jpeg
  	mm6730a2.nxml	xml

More +