A retrospective review of unintentional opioid overdose risk and mitigating factors among acutely injured trauma patients

Details

• Alternative Title:
  Drug Alcohol Depend
• Personal Author:
  Baird, Jannette ; Faul, Mark ; Green, Traci C. ; Howland, Jonathan ; Adams, Charles A. ; George, Ann ; Mello, Michael J.
• Description:
  Background
  
  Opioid medication to treat acutely injured patients is usual care in trauma settings. A higher prevalence of alcohol and other substance misuse in this population compared to the general population increases the vulnerability of such patients to both misuse of their prescribed opioids, and also unintentional opioid overdose. The primary purpose of this study was to assess the prevalence of substance use and unintentional opioid overdose risk among acutely injured trauma patients, and to examine the frequency and predictors of high opioid dose at discharge.
  
  Methods
  
  A retrospective electronic medical record (EMR) review of three-months of data from two Level 1 trauma centers. We assessed the prevalence of substance misuse, unintentional opioid overdose risk, and presence of documentation of clinical strategies to mitigate these risks, such as co-prescription of the opioid agonist naloxone.
  
  Results
  
  In total, 352 patient EMRs were examined. Over 40% of the patients reviewed had at least one indication of substance misuse (42.5% [95%CI: 37.3, 47.7]); at least 1 unintentional opioid overdose risk factor was identified in 240 EMR reviewed (68.2% [95%CI: 63.3, 73.1]). Dose of opioid medication was not significantly different for patients with substance misuse versus those without. There was no co-prescription of naloxone for any of the discharged patients.
  
  Conclusions
  
  Our results indicate that despite the high rates of substance misuse, the potential for misuse, dependence and unintentional overdose risk from prescribed opioid medications are prevalent among acutely injured trauma patients. Prescribing after acute trauma care should address these risk factors.
  
  
• Keywords:
  Adolescent Adult Aged Aged, 80 And Over Alcohol And Other Substance Use Analgesics, Opioid Drug Overdose Drug Prescriptions Electronic Health Records Female Humans Male Middle Aged Naloxone Opioid Medication Patient Discharge Retrospective Studies Risk Factors Substance-Related Disorders Trauma Centers Traumatic Injury Young Adult

  More +
• Source:
  Drug Alcohol Depend. 178:130-135
• Pubmed ID:
  28647680
• Pubmed Central ID:
  PMC6070343
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  178
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f5e9bce0fd7ba2d6d50275c93ebe26ef0fbbf9f10faaf8f7774783b65fcffcd7
• Download URL:
  https://stacks.cdc.gov/view/cdc/57799/cdc_57799_DS1.pdf
• File Type:
  [PDF - 220.26 KB ]