Details:

Alternative Title:
J Pediatr
Personal Author:
Sarkar, Subrata ; Shankaran, Seetha ; Barks, John ; Do, Barbara T. ; Laptook, Abbot R. ; ... More +
Sarkar, Subrata ; Shankaran, Seetha ; Barks, John ; Do, Barbara T. ; Laptook, Abbot R. ; Das, Abhik ; Ambalavanan, Namasivayam ; Van Meurs, Krisa P. ; Bell, Edward F. ; Sanchez, Pablo J. ; Hintz, Susan R. ; Wyckoff, Myra H. ; Stoll, Barbara J. ; Carlo, Waldemar A. Less -
Description:
Objective

To determine the outcome of preterm infants whose cystic periventricular leukomalacia “disappeared” on serial screening cranial imaging studies.

Study design

Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18–26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression.

Results

Of 7063 eligible infants, 433 (6.1%) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18%), persisted in 87 (20%), and 270 (62%) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3% and 13%. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53%] vs 1776 of 6376 [28%]; OR [95% CI] 2.8 [1.8–4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively).

Conclusions

Infants with “disappeared” cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.


Subject:
[+]
Article

Source:
J Pediatr. 195:59-65.e3.
Pubmed ID:
29398046
Pubmed Central ID:
PMC6061924
Document Type:
Journal Article
Funding:
U2G PS000658/PS/NCHHSTP CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b73fc102fb32fa9093629a00f170078ad9c9a614e474286448ff30ca6259391e
File Type:

Supporting Files

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  	nihms981996f1.jpg	jpeg

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