The Contribution of Family History to the Burden of Diagnosed Diabetes, Undiagnosed Diabetes and Prediabetes in the United States: Analysis of National Health and Nutrition Examination Survey, 2009-2014

Details

• Personal Author:
  Moonesinghe, Ramal ; Beckles, Gloria L. A. ; Liu, Tiebin ; Khoury, Muin J.
• Description:
  Purpose
  
  Given the importance of family history in the early detection and prevention of type 2 diabetes, we quantified the public health impact of reported family health history on diagnosed diabetes (DD), undiagnosed diabetes (UD), and prediabetes (PD) in the United States.
  
  Methods
  
  We used population data from the National Health Examination and Nutrition Survey 2009 to 2014 to measure the association of reported family history of diabetes with DD, UD, and PD.
  
  Results
  
  Using polytomous logistic regression and multivariable adjustment, family history prevalence ratios were 4.27 (CI: 3.57, 5.12) for DD, 2.03 (CI: 1.56, 2.63) for UD, and 1.26 (CI: 1.09, 1.44) for PD. In the United States, we estimate that 10.1 million DD cases, 1.4 million UD cases, and 3.9 million PD cases can be attributed to having a family history of diabetes.
  
  Conclusions
  
  These findings confirm that family history of diabetes has a major public health impact on diabetes in the United States. In spite of the recent interest and focus on genomics and precision medicine, family health history continues to be an integral component of public health campaigns to identify persons at high risk for developing type 2 diabetes and early detection of diabetes to prevent or delay complications.
  
  
• Subjects:
  Adult Article Diabetes Mellitus, Type 2 Early Diagnosis Female Humans Logistic Models Male Mass Screening Middle Aged Nutrition Surveys Prediabetic State Risk Factors

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• Source:
  Genet Med. 20(10):1159-1166
• Pubmed ID:
  29369292
• Pubmed Central ID:
  PMC6060023
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  20
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e18edaea96ed250508e57c75cd77f395357313eb74ed9beef8868c1d2b519401
• Download URL:
  https://stacks.cdc.gov/view/cdc/57636/cdc_57636_DS1.pdf
• File Type:
  [PDF - 108.01 KB ]