Morbidity and Mortality Weekly Report: Recommendations and Reports, April 28, 1995 / Vol. 44 / No. RR-4

Details

• Alternative Title:
  1995 Revised Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with or Perinatally Exposed to Human Immunodeficiency Virus
• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports
• Personal Author:
  Grubman, Samuel ; Moseley, Robin R. ; Oleske, James M. ; Rogers, Martha F. ; Simonds, Robert J.
• Corporate Authors:
  National Center for Infectious Diseases (U.S.). Division of HIV/AIDS. ; National Pediatric & Family HIV Resource Center (U.S.) ; Working Group on PCP Prophylaxis in Children
• Description:
  "Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in children who have acquired immunodeficiency syndrome (AIDS). Despite the publication of guidelines for prophylaxis against PCP for children infected with human immunodeficiency virus (HIV) in 1991 (1), ongoing AIDS surveillance has detected no substantial decrease in PCP incidence among HIV-infected infants. Studies indicate that this continued incidence is associated with failure to identify HIV-infected children before PCP occurs and with limitations in the ability of CD4+ measurements to identify children at risk for PCP. In March 1994, the National Pediatric & Family HIV Resource Center, in collaboration with CDC, convened a working group to review additional data about the occurrence of PCP among HIV-infected children and to reevaluate the 1991 PCP prophylaxis guidelines for children. This report summarizes these new data and presents revised PCP prevention guidelines that recommend a) promptly identifying children born to HIV-infected women and initiating regular diagnostic and immunologic monitoring of such children; b) beginning PCP prophylaxis at 4-6 weeks of age for all children who have been perinatally exposed to HIV; c) continuing prophylaxis through 12 months of age for HIV-infected children; and d) making decisions regarding prophylaxis for HIV-infected children > or = 12 months of age based on CD4+ measurements and whether PCP previously has occurred." - p. 1
• Content Notes:
  Includes bibliographical references (p. 10-11).
• Subjects:
  AIDS-Related Opportunistic Infections / Immunology AIDS-Related Opportunistic Infections / Prevention & Control AIDS Serodiagnosis Anti-Infective Agents / Therapeutic Use CD4 Lymphocyte Count Chemoprevention / Standards Child, Preschool HIV Infections / Congenital HIV Infections / Diagnosis HIV Infections / Transmission Infant Infant, Newborn Infectious Disease Transmission, Vertical Pneumonia, Pneumocystis Trimethoprim-Sulfamethoxazole Combination

  More +
• Source:
  Morbidity and Mortality Weekly Report (MMWR): Recommendations and Reports, 1995; v. 44, no. 4
• Series:
  Recommendations and Reports: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  1057-5987 (print)
• Document Type:
  Text
• Genre:
  Journal Issue
• Place as Subject:
  United States
• Pages in Document:
  18 pdf pages
• Volume:
  44
• Issue:
  4
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:e41e2c74e169737af6c895149a9c9591f6d40928fa5a1c163671de4ec4bc52dedd2b33f8d7cf01ded25a0cdc8f427b56606ab796f3f4813f0fc960dfdea3bc85
• Download URL:
  https://stacks.cdc.gov/view/cdc/5737/cdc_5737_DS1.pdf
• File Type:
  [PDF - 192.21 KB ]