Effect of Age at Vaccination on Rotavirus Vaccine Effectiveness in Bolivian Infants

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Burke, Rachel M. ; Tate, Jacqueline E. ; Pringle, Kimberly D. ; Patel, Manish ; De Oliveira, Lucia H. ; Parashar, Umesh D.
• Description:
  Background
  
  Rotavirus vaccines are less effective in developing countries versus developed countries. One hypothesis for this difference in performance is that higher levels of maternal antibodies in developing countries may interfere with vaccine response, suggesting that delayed dosing could be beneficial. The present analysis aims to assess whether rotavirus vaccine effectiveness (VE) varies by age at vaccination during routine use in Bolivia.
  
  Methods
  
  Data were merged from two post-licensure evaluations of monovalent rotavirus vaccine (RV1) in Bolivia, where two doses of RV1 are recommended at two and four months of age. For each dose, children were classified as receiving each dose “early,” “on-time,” or “late.” Stratified unconditional logistic regression models were used to estimate VE, using unvaccinated children as the referent. VE was calculated as (1 – odds ratio) × 100%. Models were adjusted for hospital, age, and time since RV1 introduction (via including terms for month and year of birth).
  
  Results
  
  VE for two doses of RV1 tended to be higher in infants receiving the first dose early (VE 92%; 95% confidence interval [CI] [70%, 98%]), when compared to infants receiving their first dose on time (72% [62%, 81%]) or late (68% [51%, 79%]). Estimates of VE were not substantially different when comparing children by age at second dose (early: VE 76% [50%, 89%]; on time: VE 70% [50%, 89%]; late: VE 75% [60%, 84%]), including all children.
  
  Conclusions
  
  Our results indicate that early administration may improve VE and support the current WHO recommendations for the RV1 schedule.
  
  
• Subjects:
  Age Factors Article Case-Control Studies Developing Countries Female Gastroenteritis Global Health Hospitalization Humans Immunization Schedule Infant Logistic Models Male Odds Ratio Rotavirus Infections Rotavirus Vaccines Vaccination Vaccine Potency

  More +
• Source:
  Pediatr Infect Dis J. 37(8):e216-e221
• Pubmed ID:
  29341984
• Pubmed Central ID:
  PMC6043377
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Place as Subject:
  Bolivia
• Volume:
  37
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d2b83e19c96cf1b2ddd7cec5b17c4c2dc421881483fea607046ec35245f5eb9c
• Download URL:
  https://stacks.cdc.gov/view/cdc/56980/cdc_56980_DS1.pdf
• File Type:
  [PDF - 202.82 KB ]