Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Hsu, Christopher H. ; Farland, Julien ; Winters, Thomas ; Gunn, Julia ; Caron, Donna ; ... More +
Hsu, Christopher H. ; Farland, Julien ; Winters, Thomas ; Gunn, Julia ; Caron, Donna ; Evans, Jennifer ; Osadebe, Lynda ; Bethune, Leon ; McCollum, Andrea M. ; Patel, Nishi ; Wilkins, Kimberly ; Davidson, Whitni ; Petersen, Brett ; Barry, M. Anita Less -
Description:
On November 26, 2013, the CDC poxvirus laboratory was notified by the Boston Public Health Commission (BPHC) of an inadvertent inoculation of a recently vaccinated (ACAM2000 smallpox vaccine) laboratory worker with wild type vaccinia virus (VACV) Western Reserve. A joint investigation by CDC and BPHC confirmed orthopoxvirus infection in the worker, who had reported a needle stick in his thumb while inoculating a mouse with VACV. He experienced a non-tender, red rash on his arm, diagnosed at a local emergency department as cellulitis. He subsequently developed a necrotic lesion on his thumb, diagnosed as VACV infection. Three weeks after the injury, the thumb lesion was surgically debrided and at 2 months post-injury, the skin lesion had resolved. The investigation confirmed that the infection was the first reported VACV infection in the United States in a laboratory worker vaccinated according to the Advisory Committee on Immunization Practices (ACIP) recommendations. The incident prompted the academic institution to outline biosafety measures for working with biologic agents, such as biosafety training of laboratory personnel, vaccination (if appropriate), and steps in incident reporting. Though vaccination has been shown to be an effective measure in protecting personnel in the laboratory setting, this case report underscores the importance of proper safety measures and incident reporting.
Subject:
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Adult Animals Articles Cefazolin Cellulitis Humans Infusions, Intravenous Laboratory Personnel Male Massachusetts Mice Needlestick Injuries Occupational Injuries Orthopoxvirus Poxviridae Infections Smallpox Vaccine Vaccinia Vaccinia Virus
Source:
MMWR Morb Mortal Wkly Rep. 2015; 64(16):435-438.
Pubmed ID:
25928468
Pubmed Central ID:
PMC4584810
Document Type:
Journal Article
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
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urn:sha256:6575752577768aba40812ad4057d892389b1393a562e57f7c3623432a64b3568
Download URL:
https://stacks.cdc.gov/view/cdc/56818/cdc_56818_DS1.pdf
File Type:

Supporting Files

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