Genotypic Characterization of Rickettsia bellii Reveals Distinct Lineages in the United States and South America

Details

• Alternative Title:
  Biomed Res Int
• Personal Author:
  Krawczak, Felipe S. ; Labruna, Marcelo B. ; Hecht, Joy A. ; Paddock, Christopher D. ; Karpathy, Sandor E.
• Description:
  The bacterium | belongs to a basal group of rickettsiae that diverged prior to the pathogenic spotted fever group and typhus group | species. Despite a diverse representation of | across more than 25 species of hard and soft ticks in the American continent, phylogeographical relationships among strains of this basal group-| species are unknown; the work described here explores these relationships. DNA was extracted from 30 | tick isolates: 15 from the United States, 14 from Brazil, and 1 from Argentina. A total of 2,269 aligned nucleotide sites of 3 protein coding genes (|A, |A, and |A) and 2 intergenic regions (|E|A| and |A|) were concatenated and subjected to phylogenetic analysis by Bayesian methods. Results showed a separation of almost all isolates between North and South Americas, suggesting that they have radiated within their respective continents. Phylogenetic positions of the 30 isolates could be a result of not only their geographical origin but also the tick hosts they have coevolved with. Whether | originated with ticks in North or South America remains obscure, as our analyses did not show evidence for greater genetic divergence of | in either continent.
• Subjects:
  Research Article
• Source:
  Biomed Res Int. 2018; 2018.
• Pubmed ID:
  29850579
• Pubmed Central ID:
  PMC5911327
• Document Type:
  Journal Article
• Place as Subject:
  South America ; United States
• Volume:
  2018
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:efb80ed4be2ebbb05d559cccbbc16f1c3940fb2ce3180cd50383dcad2c121ba9
• Download URL:
  https://stacks.cdc.gov/view/cdc/56524/cdc_56524_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]