Evaluation of Automated Molecular Testing Rollout for Tuberculosis Diagnosis Using Routinely Collected Surveillance Data — Uganda, 2012–2015

Scott, Colleen; Walusimbi, Simon; Kirenga, Bruce; Joloba, Moses; Winters, Muttamba; Abdunoor, Nyombi; Bain, Rommel; Alexander, Heather; Shinnick, Tom; Toney, Sean; Odeke, Rosemary; Mwangi, Christine; Birabwa, Estella; Dejene, Seyoum; Mugabe, Frank; YaDiul, Mukadi; Cavanaugh, J. Sean

doi:10.15585/mmwr.mm6612a6

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Evaluation of Automated Molecular Testing Rollout for Tuberculosis Diagnosis Using Routinely Collected Surveillance Data — Uganda, 2012–2015

Published Date:

Mar 31 2017

Publisher's site:

http://dx.doi.org/10.15585/mmwr.mm6612a6 New Site Icon

Source:

MMWR Morb Mortal Wkly Rep. 66(12):339-342.

[PDF-239.31 KB]

Details:

Personal Authors:

Scott, Colleen ; Walusimbi, Simon ; Kirenga, Bruce ; Joloba, Moses ; Winters, Muttamba ; ... More ▼

Keywords:

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Pubmed ID:

28358797

Pubmed Central ID:

PMC5657957

Description:

In 2012, Uganda introduced the use of GeneXpert MTB/RIF (Cepheid, Sunnyvale CA), a sensitive, automated, real-time polymerase chain reaction-based platform for tuberculosis (TB) diagnosis, for programmatic use among children, adults with presumptive human immunodeficiency virus (HIV)-associated TB, and symptomatic persons at risk for rifampicin (RIF)-resistant TB. The effect of using the platform's Xpert MTB/RIF assay on TB care and control was assessed using routinely collected programmatic data; in addition, a retrospective review of district quarterly summaries using abstracted TB register data from purposively selected facilities in the capital city of Kampala was conducted. Case notification rates were calculated and nonparametric statistical methods were used for analysis. No statistically significant differences were observed in case notification rates before and after the Xpert MTB/RIF assay became available, although four of 10 districts demonstrated a statistically significant difference in bacteriologically confirmed TB. Once the GeneXpert MTB/RIF platform is established and refined, a more comprehensive evaluation should be conducted.

Document Type:

Journal Article

Collection(s):

Morbidity and Mortality Weekly Report (MMWR)

Place as Subject:

Uganda

Main Document Checksum:

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Supporting Files:

mm6612a6.nxml

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