Evaluation of Automated Molecular Testing Rollout for Tuberculosis Diagnosis Using Routinely Collected Surveillance Data — Uganda, 2012–2015

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Scott, Colleen ; Walusimbi, Simon ; Kirenga, Bruce ; Joloba, Moses ; Winters, Muttamba ; Abdunoor, Nyombi ; Bain, Rommel ; Alexander, Heather ; Shinnick, Tom ; Toney, Sean ; Odeke, Rosemary ; Mwangi, Christine ; Birabwa, Estella ; Dejene, Seyoum ; Mugabe, Frank ; YaDiul, Mukadi ; Cavanaugh, J. Sean
• Corporate Authors:
  Centers for Dsease Control and Prevention (U.S.)Epidemic Intelligence Service. ; Center for Global Health (U.S.)Division of Global HIV and TB.
• Description:
  In 2012, Uganda introduced the use of GeneXpert MTB/RIF (Cepheid, Sunnyvale CA), a sensitive, automated, real-time polymerase chain reaction-based platform for Tuberculosis (TB) Diagnosis, for programmatic use among children, adults with presumptive human immunodeficiency Virus (HIV)-associated TB, and symptomatic persons at risk for rifampicin (RIF)-resistant TB. The effect of using the platform's Xpert MTB/RIF assay on TB care and control was assessed using routinely collected programmatic data; in addition, a retrospective review of district quarterly summaries using abstracted TB register data from purposively selected facilities in the capital city of Kampala was conducted. Case notification rates were calculated and nonparametric statistical Methods were used for Analysis. No statistically significant differences were observed in case notification rates before and after the Xpert MTB/RIF assay became available, although four of 10 districts demonstrated a statistically significant difference in bacteriologically confirmed TB. Once the GeneXpert MTB/RIF platform is established and refined, a more comprehensive evaluation should be conducted.
• Subjects:
  Adult Automation, Laboratory Child Drug Resistance, Multiple Full Report HIV Infections Humans Molecular Diagnostic Techniques Mycobacterium Tuberculosis Population Surveillance Retrospective Studies Tuberculosis

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(12):339-342.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6612a6
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  28358797
• Pubmed Central ID:
  PMC5657957
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Pages in Document:
  4 pdf pages
• Volume:
  66
• Issue:
  12
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:eb5e6a9209c5a15499db195fc7ecea061b5815c641a5ced0cc54b03994891f94530319a08771f0c717a38d73fb1cd808392e0bcb6317bb35096e8eed35c2b7b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/55753/cdc_55753_DS1.pdf
• File Type:
  [PDF - 239.31 KB ]