Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Publisher's site:
http://dx.doi.org/10.15585/mmwr.mm6612a6
Personal Author:
Scott, Colleen ; Walusimbi, Simon ; Kirenga, Bruce ; Joloba, Moses ; Winters, Muttamba ; ... More +
Scott, Colleen ; Walusimbi, Simon ; Kirenga, Bruce ; Joloba, Moses ; Winters, Muttamba ; Abdunoor, Nyombi ; Bain, Rommel ; Alexander, Heather ; Shinnick, Tom ; Toney, Sean ; Odeke, Rosemary ; Mwangi, Christine ; Birabwa, Estella ; Dejene, Seyoum ; Mugabe, Frank ; YaDiul, Mukadi ; Cavanaugh, J. Sean ; Less -
Corporate Authors:
Centers for Dsease Control and Prevention (U.S.). Epidemic Intelligence Service. ; Center for Global Health (U.S.). Division of Global HIV and TB. ;
Centers for Dsease Control and Prevention (U.S.). Epidemic Intelligence Service. ; Center for Global Health (U.S.). Division of Global HIV and TB. ; Less -
Description:
In 2012, Uganda introduced the use of GeneXpert MTB/RIF (Cepheid, Sunnyvale CA), a sensitive, automated, real-time polymerase chain reaction-based platform for tuberculosis (TB) diagnosis, for programmatic use among children, adults with presumptive human immunodeficiency virus (HIV)-associated TB, and symptomatic persons at risk for rifampicin (RIF)-resistant TB. The effect of using the platform's Xpert MTB/RIF assay on TB care and control was assessed using routinely collected programmatic data; in addition, a retrospective review of district quarterly summaries using abstracted TB register data from purposively selected facilities in the capital city of Kampala was conducted. Case notification rates were calculated and nonparametric statistical methods were used for analysis. No statistically significant differences were observed in case notification rates before and after the Xpert MTB/RIF assay became available, although four of 10 districts demonstrated a statistically significant difference in bacteriologically confirmed TB. Once the GeneXpert MTB/RIF platform is established and refined, a more comprehensive evaluation should be conducted.
Subject:
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Adult
Automation, Laboratory
Child
Drug Resistance, Multiple
Full Report
HIV Infections
Humans
Molecular Diagnostic Techniques
Mycobacterium Tuberculosis
Population Surveillance
Retrospective Studies
Tuberculosis

Source:
MMWR Morb Mortal Wkly Rep. 66(12):339-342.
Pubmed ID:
28358797
Pubmed Central ID:
PMC5657957
Document Type:
Journal Article ;
Place as Subject:
Uganda ;
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:4595906014b13224bfdc9bc1666b1f38aa26a8b31981b13dd7de6066c876a1a3
File Type:

Supporting Files

• mm6612a6.nxml

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