Interaction profile for uranium, fluoride, cyanide, and nitrate
Published Date:May 2004
Corporate Authors:United States, Agency for Toxic Substances and Disease Registry., Division of Toxicology. ; Syracuse Research Corporation ;
Funding:Prepared under contract no. 205-97-0622. by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Chemical manager(s)/author(s): Mike Fay, ATSDR, Division of Toxicology, Atlanta, GA; Mark Osier, Joan Colman, Syracuse Research Corporation, Syracuse, NY.
Description:1. Introduction -- 2. Joint toxic action data for the mixture of concern and component mixtures -- 3. Recommendation for exposure-based assessment of joint toxic action of the mixture -- 4. Conclusions -- 5. List of references -- Appendix A. Background information for Uranium -- Appendix B. Background information for Fluoride -- Appendix C. Background information for Cyanide -- Appendix D. Background information for Nitrate
"Uranium and fluoride are used in conjunction with nitrate when separating isotopes of uranium via the gaseous diffusion process. This process has been used at several U.S. Department of Energy (DOE) facilities, and continues to be used today. In addition, cyanide has been reported with great frequency as a contaminant at NPL sites. Review of ATSDR's documents with site-specific information showed that uranium, fluoride, cyanide, and nitrate were reported at one site (Pantax Plant site), while threecomponent submixtures were reported at eight additional sites: Eastern Michaud Flats, Monticello Mill, Alcoa/Lavaca Bay, Depue/New Jersey Zinc/Mobil Chemical, Hipps Road Landfill, Riverbank Army Ammunition Plant, Savanna Army Depot, and Santa Susana Field Laboratory. The purposes of this profile are to: (1) evaluate data (if available) on health hazards, and their dose-response relationships, from oral exposure to this four-component mixture; (2) evaluate data on the joint toxic actions of components of this mixture; and (3) make recommendations for exposure-based assessments of the potential impact of joint toxic action of the mixture on public health." - p. ix
Supporting Files:No Additional Files
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