Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
McKenney, Jennie ; Smith, Rachel M. ; Chiller, Tom M. ; Detels, Roger ; French, Audrey ; ... More +
McKenney, Jennie ; Smith, Rachel M. ; Chiller, Tom M. ; Detels, Roger ; French, Audrey ; Margolick, Joseph ; Klausner, Jeffrey D. Less -
Description:
Cryptococcal meningitis (CM) is one of the leading opportunistic infections associated with human immunodeficiency virus (HIV) infection. The worldwide burden of CM among persons living with HIV/acquired immunodeficiency syndrome (AIDS) was estimated in 2009 to be 957,900 cases, with approximately 624,700 deaths annually. The high burden of CM globally comes despite the fact that cryptococcal antigen (CrAg) is detectable weeks before the onset of symptoms, allowing screening for cryptococcal infection and early treatment to prevent CM and CM-related mortality (2). However, few studies have been conducted in the United States to assess the prevalence of cryptococcal infection. To quantify the prevalence of undiagnosed cryptococcal infection in HIV-infected persons in the United States during 1986-2012, stored sera from 1,872 participants in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study with CD4 T-cell counts <100 cells/µL were screened for CrAg, using the CrAg Lateral Flow Assay (LFA) (Immy, Inc.). This report describes the results of that analysis, which indicated the overall prevalence of CrAg positivity in this population to be 2.9% (95% confidence interval [CI] = 2.2%-3.7%).
Subject:
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Adult
Aged
AIDS-Related Opportunistic Infections
Antigens, Fungal
CD4 Lymphocyte Count
Cohort Studies
Cryptococcus
Ethnicity
Female
Humans
Male
Meningitis, Cryptococcal
Middle Aged
Prevalence
Risk Factors
Young Adult

Source:
MMWR Morb Mortal Wkly Rep. 2014; 63(27):585-587.
Pubmed ID:
25006824
Pubmed Central ID:
PMC4584711
Document Type:
Journal Article
Funding:
P30 AI028697/AI/NIAID NIH HHS/United States ; U01 AI035042/AI/NIAID NIH HHS/United States ; UL1 TR000124/TR/NCATS NIH HHS/United States ; UM1 AI035043/AI/NIAID NIH HHS/United States
P30 AI028697/AI/NIAID NIH HHS/United States ; U01 AI035042/AI/NIAID NIH HHS/United States ; UL1 TR000124/TR/NCATS NIH HHS/United States ; UM1 AI035043/AI/NIAID NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:0e935ee63c2f6a7856d3d9e5e181cd454f972b43b9ed9cc057d0947e70bb32f5
File Type:

Supporting Files

• 585-587.nxml

  xml

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