Prevalence and Correlates of Cryptococcal Antigen Positivity Among AIDS Patients — United States, 1986–2012

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  McKenney, Jennie ; Smith, Rachel M. ; Chiller, Tom M. ; Detels, Roger ; French, Audrey ; Margolick, Joseph ; Klausner, Jeffrey D.
• Description:
  Cryptococcal meningitis (CM) is one of the leading opportunistic infections associated with human immunodeficiency Virus (HIV) infection. The Worldwide burden of CM among persons living with HIV/acquired immunodeficiency syndrome (AIDS) was estimated in 2009 to be 957,900 cases, with approximately 624,700 deaths annually. The high burden of CM globally comes despite the fact that cryptococcal antigen (CrAg) is detectable weeks before the onset of symptoms, allowing screening for cryptococcal infection and early treatment to prevent CM and CM-related Mortality (2). However, few studies have been conducted in the United States to assess the prevalence of cryptococcal infection. To quantify the prevalence of undiagnosed cryptococcal infection in HIV-infected persons in the United States during 1986-2012, stored sera from 1,872 participants in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study with CD4 T-cell counts <100 cells/µL were screened for CrAg, using the CrAg Lateral Flow Assay (LFA) (Immy, Inc.). This report describes the results of that Analysis, which indicated the overall prevalence of CrAg positivity in this population to be 2.9% (95% confidence interval [CI] = 2.2%-3.7%).
• Subjects:
  Adult Aged AIDS-Related Opportunistic Infections Antigens, Fungal CD4 Lymphocyte Count Cohort Studies Cryptococcus Ethnicity Female Humans Male Meningitis, Cryptococcal Middle Aged Prevalence Risk Factors Young Adult

  More +
• Source:
  MMWR Morbidity Mortal Weekly Rep. 2014; 63(27):585-587.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  25006824
• Pubmed Central ID:
  PMC4584711
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  3 pdf pages
• Volume:
  63
• Issue:
  27
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:d840148aa3e95fa581e897b84c739553913fe014bebe662fc8c6e681e00b0877a0c89c3c1ba5164bda8016ca37e502aa767d4ab419eb53eeaa8ace8a54e0954d
• Download URL:
  https://stacks.cdc.gov/view/cdc/54912/cdc_54912_DS1.pdf
• File Type:
  [PDF - 151.55 KB ]