Shigella with Decreased Susceptibility to Azithromycin Among Men Who Have Sex with Men — United States, 2002–2013

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Heiman, Katherine E. ; Karlsson, Maria ; Grass, Julian ; Howie, Becca ; Kirkcaldy, Robert D. ; Mahon, Barbara ; Brooks, John T. ; Bowen, Anna
• Description:
  Bacteria of the genus Shigella cause approximately 500,000 illnesses each year in the United States Diarrhea (sometimes bloody), fever, and stomach cramps typically start 1-2 days after exposure and usually resolve in 5-7 days. For patients with severe disease, bloody diarrhea, or compromised immune systems, antibiotic treatment is recommended, but resistance to traditional first-line antibiotics (e.g., ampicillin and trimethoprim-sulfamethoxazole) is common. For multidrugresistant cases, azithromycin, the most frequently prescribed antibiotic in the United States, is recommended for both children and adults. However, not all Shigellae are susceptible to azithromycin. Nonsusceptible isolates exist but are not usually identified because there are no clinical laboratory guidelines for azithromycin susceptibility tTesting. However, to monitor susceptibility of Shigellae in the United States, CDC's National Antimicrobial Resistance Monitoring System (NARMS) has, since 2011, routinely measured the azithromycin minimum inhibitory concentration (MIC) for every 20th Shigella isolate submitted from public health laboratories to CDC, as well as outbreak-associated isolates. All known U.S. Shigella isolates with decreased susceptibility to azithromycin (DSA-Shigella), and the illnesses caused by them, are described in this report.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Azithromycin Child Child, Preschool Drug Resistance, Bacterial Dysentery, Bacillary Female Homosexuality, Male Humans Infant Male Middle Aged Shigella Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 2014; 63(6):132-133.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  24522098
• Pubmed Central ID:
  PMC4584870
• Document Type:
  Journal Article
• Genre:
  Notes from the Field
• Place as Subject:
  United States
• Pages in Document:
  2 pdf pages
• Volume:
  63
• Issue:
  6
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:32b776472396c433ada2f735851312a995a92ac60a47f1b5ef6bc4c33b44d4aada6c3c8fca10181d3fb4078db0af21627b47e970d1c9040758b8ac3cbbae70ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/54808/cdc_54808_DS1.pdf
• File Type:
  [PDF - 107.62 KB ]