Late Vitamin K Deficiency Bleeding in Infants Whose Parents Declined Vitamin K Prophylaxis — Tennessee, 2013

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Warren, Michael ; Miller, Angela ; Traylor, Julie ; Sidonio, Robert ; Morad, Anna ; Goodman, Alyson ; Christensen, Deborah ; Grant, Althea ; Odom, Erika ; Okoroh, Ekwutosi ; Clayton, Joshua ; Maenner, Matthew ; Marcewicz, Lauren
• Description:
  Vitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is limited; cord blood and infant liver reserve levels of vitamin K are substantially below adult levels. As a result, infants are predisposed to develop VKDB, which is classified as early, classic, and late, according to when it presents. In the United States, administration of intramuscular vitamin K at birth to prevent all forms of VKDB has been standard practice since first recommended by the American Academy of Pediatrics in 1961. Without this prophylaxis, incidence of early and classical VKDB ranges from 0.25% to 1.7% of births; incidence of late VKDB ranges from 4.4 to 7.2 per 100,000 infants. The relative risk for developing late VKDB has been estimated at 81 times greater among infants who do not receive intramuscular vitamin K than in infants who do receive it.
• Subjects:
  Antifibrinolytic Agents Health Knowledge, Attitudes, Practice Humans Infant Infant, Newborn Injections, Intramuscular Notes From The Field Parents Risk Assessment Treatment Refusal Vitamin K Vitamin K Deficiency Bleeding

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 2013; 62(45):901-902.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  24226627
• Pubmed Central ID:
  PMC4585350
• Document Type:
  Journal Article
• Place as Subject:
  Tennessee
• Pages in Document:
  2 pdf pages
• Volume:
  62
• Issue:
  45
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:40fd1508249d1226337bcc6bc1eb2a951b431402791356b49cfe96569fe5e137ab3bf67e291b1a7f2ef0248f641af2b3e0e2e3e1a73cf3a716c2192d6912bf7d
• Download URL:
  https://stacks.cdc.gov/view/cdc/54770/cdc_54770_DS1.pdf
• File Type:
  [PDF - 98.49 KB ]