Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Publisher's site:
http://dx.doi.org/10.15585/mmwr.mm6631a2
Personal Author:
Bonwitt, Jesse ; Poel, Amy ; DeBolt, Chas ; Gonzales, Elysia ; Lopez, Adriana ; ... More +
Bonwitt, Jesse ; Poel, Amy ; DeBolt, Chas ; Gonzales, Elysia ; Lopez, Adriana ; Routh, Janell ; Rietberg, Krista ; Linton, Natalie ; Reggin, James ; Sejvar, James ; Lindquist, Scott ; Otten, Catherine Less -
Description:
In October 2016, Seattle Children's Hospital notified the Washington State Department of Health (DOH) and CDC of a cluster of acute onset of limb weakness in children aged ≤14 years. All patients had distinctive spinal lesions largely restricted to gray matter detected by magnetic resonance imaging (MRI), consistent with acute flaccid myelitis (AFM). On November 3, DOH issued a health advisory to local health jurisdictions requesting that health care providers report similar cases. By January 24, 2017, DOH and CDC had confirmed 10 cases of AFM and excluded two suspected cases among residents of Washington during September-November 2016. Upper respiratory tract, stool, rectal, serum, buccal, and cerebrospinal fluid (CSF) specimens were tested for multiple pathogens. Hypothesis-generating interviews were conducted with patients or their parents to determine commonalities between cases. No common etiology or source of exposure was identified. Polymerase chain reaction (PCR) testing detected enterovirus D68 (EV-D68) in nasopharyngeal swabs of two patients, one of whom also tested positive for adenovirus by PCR, and detected enterovirus A71 (EV-A71) in the stool of a third patient. Mycoplasma spp. immunoglobulin M (IgM) titer was elevated in two patients, but both had upper respiratory swabs that tested negative for Mycoplasma spp. by PCR. Clinicians should maintain vigilance for AFM and report cases as soon as possible to state or local health departments.
Subject:
[+]
Acute Disease
Adolescent
Child
Child, Preschool
Cluster Analysis
Female
Humans
Male
Myelitis
Outbreak Report
Paralysis
Washington

Source:
MMWR Morb Mortal Wkly Rep. 66(31):826-829.
Pubmed ID:
28796760
Pubmed Central ID:
PMC5687781
Document Type:
Journal Article
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:77b7d58e5467b9b02ec12a13199b6939a737c7729e9ab8f313169db2a0998329
File Type:

Supporting Files

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  	mm6631a2-F.jpg	jpeg
  	mm6631a2.nxml	xml

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