Solid Organ Transplant–Transmitted Tuberculosis Linked to a Community Outbreak — California, 2015

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Kay, Alexander ; Barry, Pennan M. ; Annambhotla, Pallavi ; Greene, Carol ; Cilnis, Martin ; Chin-Hong, Peter ; Arger, Nicholas ; McNitt, Louise ; Neidlinger, Nikole ; Shah, Neha ; Basavaraju, Sridhar V. ; Kuehnert, Matthew ; Shaw, Tambi
• Corporate Authors:
  National Center for Emerging and Zoonotic Infectious Diseases (U.S.)Division of Healthcare Quality Promotion. ; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.)Division of TB Elimination.
• Description:
  In the spring of 2015, a local health department (LHD) in county A notified the California Department of Public Health (CDPH) about three adults with close ties to one another and a congregate community site who had received diagnoses of Tuberculosis (TB) disease within a 3-month period. Subsequent review revealed matching TB genotypes indicating that the cases were likely part of a chain of TB Transmission. Only three TB cases in California in the preceding 2 years shared this same genotype. One of those three previous cases occurred in a lung-transplant recipient who had no identified epidemiologic links to the outbreak. CDPH, multiple LHDs, and CDC conducted an investigation and determined that the lung-transplant donor (patient 1) was epidemiologically linked to the three outbreak cases and had a tuberculin skin test (TST) conversion detected in 2012 upon reentry at a local jail. Three other solid organ recipients from this donor were identified; none had developed TB disease. This investigation suggests that review of organ donors' medical records from high-risk environments, such as jails, might reveal additional information about TB risk. The evaluation of TB in organ recipients could include genotyping Analysis (1) and coordination among local, state, and national partners to evaluate the potential for donor-derived TB.
• Subjects:
  Adult Disease Outbreaks Full Report Genotype Humans Organ Transplantation Tuberculosis
• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(30):801-805.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6630a1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  28771459
• Pubmed Central ID:
  PMC5720876
• Document Type:
  Journal Article
• Place as Subject:
  California
• Pages in Document:
  5 pdf pages
• Volume:
  66
• Issue:
  30
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:858343a4f477c3d26ccc098258ffaed5d95dda3b0b9d194ea67b70c68d1e5b99dd455975adb7b8225f6696a418254e8e89e427096544e300a7e4dcb3b11d68d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/54569/cdc_54569_DS1.pdf
• File Type:
  [PDF - 198.10 KB ]