Mortality from Amyotrophic Lateral Sclerosis and Parkinson’s Disease Among Different Occupation Groups — United States, 1985–2011

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Beard, John D. ; Ju, Jun ; Lu, John ; Luckhaupt, Sara E. ; Schubauer-Berigan, Mary K. ; Steege, Andrea L.
• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.) ; National Institute for Occupational Safety and Health
• Description:
  Amyotrophic lateral sclerosis (ALS) and Parkinson's disease, both progressive neurodegenerative Diseases, affect >1 million Americans (1,2). Consistently reported risk factors for ALS include increasing age, male sex, and cigarette smoking (1); risk factors for Parkinson's disease include increasing age, male sex, and pesticide exposure, whereas cigarette smoking and caffeine consumption are inversely associated (2). Relative to cancer or respiratory Diseases, the role of occupation in neurologic Diseases is much less studied and less well understood (3). CDC evaluated associations between usual occupation and ALS and Parkinson's disease Mortality using data from CDC's National Institute for Occupational Safety and Health (NIOSH) National Occupational Mortality Surveillance (NOMS), a population-based Surveillance system that includes approximately 12.1 million deaths from 30 U.S. states.* Associations were estimated using proportionate Mortality ratios (PMRs), standardizing indirectly by age, sex, race, and calendar year to the standard population of all NOMS deaths with occupation information. Occupations associated with higher socioeconomic status (SES) had elevated ALS and Parkinson's disease Mortality. The shifts in the U.S. workforce toward older ages and higher SES occupations| highlight the importance of understanding this finding, which will require studies with designs that provide evidence for causality, detailed exposure assessment, and adjustment for additional potential confounders.
• Subjects:
  Amyotrophic Lateral Sclerosis Full Report Mortality Occupational Health Parkinson Disease
• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(27):718-722.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6627a2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Pubmed ID:
  28704346
• Pubmed Central ID:
  PMC5687590
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  United States
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5 pdf pages
• Volume:
  66
• Issue:
  27
• NIOSHTIC Number:
  nn:20050039
• Collection(s):
  National Institute for Occupational Safety and Health Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:e305aded452459e28623cee962393985ea7db2fabb08654bfa69bdc86f1e18ca23d6d628fb2f459048719ad9328aec13ea2d2923b7621513e31aacceeea4987d
• Download URL:
  https://stacks.cdc.gov/view/cdc/54546/cdc_54546_DS1.pdf
• File Type:
  [PDF - 175.74 KB ]