Hepatitis B Surface Antigen Screening Among Pregnant Women and Care of Infants of Hepatitis B Surface Antigen–Positive Mothers — Guam, 2014

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Abara, Winston E. ; Cha, Susan ; Malik, Tasneem ; DeSimone, Mia S. ; Schumann, Bernadette ; Mallada, Esther ; Klemme, Michael ; Aguon, Vince ; Santos, Anne Marie ; Collier, Melissa ; Kamb, Mary
• Corporate Authors:
  National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.)Division of Sexually Transmitted Diseases Prevention. ; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.)Division of Viral Hepatitis. ; Centers for Dsease Control and Prevention (U.S.)Epidemic Intelligence Service.
• Description:
  Hepatitis B Virus (HBV) infection is endemic among adults in the U.S. territory of Guam (1,2). Perinatal HBV Transmission, which occurs at birth from an infected mother to her newborn infant, is a major mode of HBV Transmission and maintains HBV endemicity (3). Approximately 90% of HBV-infected infants will develop chronic HBV infection, and approximately 25% of those will die prematurely from liver failure or hepatocellular carcinoma (4,5). Since 1988, the Advisory Committee on Immunization Practices has recommended that all pregnant women be screened for hepatitis B surface antigen (HBsAg), an indicator of HBV infection, and that infants of women who screen positive (HBsAg-positive women) receive postexposure prophylaxis (PEP) (hepatitis B vaccine and hepatitis B immunoglobulin [HBIG]). When received within 12 hours of birth, PEP is 85%-95% effective in preventing perinatal HBV Transmission (5,6). Hepatitis B vaccine provides long-term active immunity to HBV infection and HBIG provides short-term passive immunity to HBV infection until the infant responds to the vaccine (5). Hepatitis B vaccine was introduced into the routine universal infant vaccination schedule in Guam in 1988 (1).
• Subjects:
  Adolescent Adult Female Full Report Guam Hepatitis B Hepatitis B Surface Antigens Hepatitis B Vaccines Humans Immunization Schedule Immunoglobulins Infant Infectious Disease Transmission, Vertical Mass Screening Maternal-Child Health Services Middle Aged Post-Exposure Prophylaxis Pregnancy Pregnancy Complications, Infectious Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(19):506-508.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6619a5
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  28520708
• Pubmed Central ID:
  PMC5657642
• Document Type:
  Journal Article
• Place as Subject:
  Guam
• Pages in Document:
  3 pdf pages
• Volume:
  66
• Issue:
  19
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:09aa0d87cc29ec8eb7d92f616807673f295ea60d4d5bab64d77d446c69e916a7a33c2d5ed050baa755f4e9009f850b2f0a7fccc5c95bddc387781b2f014ec358
• Download URL:
  https://stacks.cdc.gov/view/cdc/54493/cdc_54493_DS1.pdf
• File Type:
  [PDF - 75.22 KB ]