In vivo measurement of bone manganese and association with manual dexterity: a pilot study

Wells, Ellen M.; Liu, Yingzi; Rolle-McFarland, Danelle; Mostafaei, Farshad; Zheng, Wei; Nie, Linda H.

doi:10.1016/j.envres.2017.09.016

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In vivo measurement of bone manganese and association with manual dexterity: a pilot study

Oct 03 2017
By Wells, Ellen M. ; Liu, Yingzi ; Rolle-McFarland, Danelle ; ...
http://dx.doi.org/10.1016/j.envres.2017.09.016
Source: Environ Res. 160:35-38

[PDF-379.02 KB]

English

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Alternative Title:

Environ Res
Personal Author:

Wells, Ellen M. ; Liu, Yingzi ; Rolle-McFarland, Danelle ; Mostafaei, Farshad ; Zheng, Wei ; ... More +

Wells, Ellen M. ; Liu, Yingzi ; Rolle-McFarland, Danelle ; Mostafaei, Farshad ; Zheng, Wei ; Nie, Linda H. Less -
Description:

We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89µg/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln(BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: β = -1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied.
Subjects:

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Adolescent Adult Article Biomarkers Bone And Bones Environmental Exposure Humans In Vivo Neutron Activation Analysis (IVNAA) Male Manganese Motor Skills Neutron Activation Analysis Pilot Projects Young Adult
Source:

Environ Res. 160:35-38
Pubmed ID:

28961467
Pubmed Central ID:

PMC5962822
Document Type:

Journal Article
Funding:

R21 OH010700/OH/NIOSH CDC HHS/United States
Volume:

160
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:d030d9a5b936907a7755c8bd82d991dac61de092fb551495b9687c1ffb4c862b
Download URL:

https://stacks.cdc.gov/view/cdc/54368/cdc_54368_DS1.pdf
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