Health and Development at Age 19–24 Months of 19 Children Who Were Born with Microcephaly and Laboratory Evidence of Congenital Zika Virus Infection During the 2015 Zika Virus Outbreak — Brazil, 2017

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Satterfield-Nash, Ashley ; Kotzky, Kim ; Allen, Jacob ; Bertolli, Jeanne ; Moore, Cynthia A. ; Pereira, Isabela Ornelas ; Pessoa, André ; Melo, Flavio ; Santelli, Ana Carolina Faria e Silva ; Boyle, Coleen A. ; Peacock, Georgina
• Description:
  In November 2015, the Brazilian Ministry of Health (MOH) declared the Zika Virus outbreak a public health emergency after an increase in microcephaly cases was reported in the northeast region of the country (1). During 2015-2016, 15 states in Brazil with laboratory-confirmed Zika Virus Transmission reported an increase in birth prevalence of microcephaly (2.8 cases per 10,000 live births), significantly exceeding prevalence in four states without confirmed Transmission (0.6 per 10,000) (2). Although children with microcephaly and laboratory evidence of Zika Virus infection have been described in early infancy (3), their subsequent health and development have not been well characterized, constraining planning for the care and support of these children and their families. The Brazilian MOH, the State Health Secretariat of Paraíba, and CDC collaborated on a follow-up investigation of the health and development of children in northeastern Brazil who were reported to national Surveillance with microcephaly at birth. Nineteen children with microcephaly at birth and laboratory evidence of Zika Virus infection were assessed through clinical evaluations, caregiver interviews, and review of medical records. At follow-up (ages 19-24 months), most of these children had severe motor impairment, seizure disorders, hearing and vision abnormalities, and sleep difficulties. Children with microcephaly and laboratory evidence of Zika Virus infection have severe functional limitations and will require specialized care from clinicians and caregivers as they age.
• Subjects:
  Case-Control Studies Child, Preschool Clinical Laboratory Techniques Developmental Disabilities Disease Outbreaks Female Follow-Up Studies Humans Infant Infant, Newborn Male Microcephaly Pregnancy Pregnancy Complications, Infectious Zika Virus Zika Virus Infection

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(49):1347-1351.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6649a2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  29240727
• Pubmed Central ID:
  PMC5730218
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Pages in Document:
  5 pdf pages
• Volume:
  66
• Issue:
  49
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:eb817b93fc581dbb41b1582d555cd99e8cc0b1c389f56078eeee5663e9ab10ab5070b944c1cb4dd9906a165097478bce057e20bec93d9cf66bd4f2e4af215249
• Download URL:
  https://stacks.cdc.gov/view/cdc/54313/cdc_54313_DS1.pdf
• File Type:
  [PDF - 107.95 KB ]