CDC Grand Rounds: Improving the Lives of Persons with Sickle Cell Disease

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Hulihan, Mary ; Hassell, Kathryn L. ; Raphael, Jean L. ; Smith-Whitley, Kim ; Thorpe, Phoebe
• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.)
• Description:
  Approximately 100,000 Americans have sickle cell disease (SCD), a group of recessively inherited red blood cell disorders characterized by abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in the red blood cells. Persons with hemoglobin SS or hemoglobin Sß| thalassemia, also known as sickle cell anemia (SCA), have the most severe form of SCD. Hemoglobin SC disease and hemoglobin Sß| thalassemia are other common forms of SCD. Red blood cells that contain sickle hemoglobin are inflexible and can stick to vessel walls, causing a blockage that slows or stops blood flow. When this happens, oxygen cannot reach nearby tissues, leading to attacks of sudden, severe pain, called pain crises, which are the clinical hallmark of SCD. The red cell sickling and poor oxygen delivery can also cause damage to the brain, spleen, eyes, lungs, liver, and multiple other organs and organ systems. These chronic Complications can lead to increased morbidity, early Mortality, or both. Tremendous strides in treating and preventing the Complications of SCD have extended life expectancy. Now, nearly 95% of persons born with SCD in the United States reach age 18 years (1); however, adults with the most severe forms of SCD have a life span that is 20-30 years shorter than that of persons without SCD (2).
• Subjects:
  Adolescent Adult Anemia, Sickle Cell Child Child, Preschool Community Health Services Continuity Of Patient Care Grand Rounds Health Policy Humans Pediatrics Public Health Practice Quality Of Life Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 66(46):1269-1271.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6646a2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  29166365
• Pubmed Central ID:
  PMC5769787
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  3 pdf pages
• Volume:
  66
• Issue:
  46
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:362164403e8774a1be15f9e1bfb15b5f85c20132866d6b6cb2ef016495531b278e210ea7ea11c9f186179c6ee1f3ffb6120851791a194204c813b46d9c05010c
• Download URL:
  https://stacks.cdc.gov/view/cdc/54294/cdc_54294_DS1.pdf
• File Type:
  [PDF - 72.68 KB ]