Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Diop, Ousmane M. ; Asghar, Humayun ; Gavrilin, Evgeniy ; Moeletsi, Nicksy Gumede ; Benito, Gloria Rey ; ... More +
Diop, Ousmane M. ; Asghar, Humayun ; Gavrilin, Evgeniy ; Moeletsi, Nicksy Gumede ; Benito, Gloria Rey ; Paladin, Fem ; Pattamadilok, Sirima ; Zhang, Yan ; Goel, Ajay ; Quddus, Arshad Less -
Description:
The Global Polio Eradication Initiative (GPEI) has made substantial progress since its launch in 1988; only 37 wild polioVirus type 1 (WPV1) cases were detected in 2016, the lowest annual count ever. Wild polioVirus type 3 has not been detected since November 2012, and wild polioVirus type 2 was officially declared eradicated in September 2015. This success is attributable to the wide use of live oral polioVirus vaccines (OPVs). Since 2001, numerous outbreaks were caused by the emergence of genetically divergent vaccine-derived polioViruses (VDPVs) whose genetic drift from the parental OPV strains indicates prolonged replication or circulation (1). In 2015, circulating VDPV type 2 (cVDPV2) outbreaks were detected in five countries Worldwide (Nigeria, Pakistan, Guinea, Burma, and South Sudan), and VDPV2 single events were reported in 22 countries. These events prompted the GPEI to withdraw the type 2 component (Sabin2) of trivalent OPV (tOPV) in a globally coordinated, synchronized manner in April 2016 (2,3), at which time all OPV-using countries switched to using bivalent OPV (bOPV), containing Sabin types 1 and 3. This report details for the first time the virologic tracking of elimination of a live vaccine that has been withdrawn from routine and mass immunization systems Worldwide (3). To secure elimination, further monitoring is warranted to detect any use of tOPV or monovalent OPV type 2 (mOPV2).
Subjects:
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Disease Eradication Disease Outbreaks Environmental Monitoring Full Report Global Health Humans Laboratories Mass Vaccination Paralysis Poliomyelitis PolioVirus PolioVirus Vaccine, Oral Population Surveillance Product Recalls And Withdrawals Sewage Vaccines, Attenuated
Source:
MMWR Morb Mortal Wkly Rep. 66(20):538-542.
Pubmed ID:
28542124
Pubmed Central ID:
PMC5657872
Document Type:
Journal Article
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
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urn:sha256:7c3165008d9a6f3118df0583eca60f8117cfbc643a9aa7dd04ca94b05c5ca468
Download URL:
https://stacks.cdc.gov/view/cdc/54097/cdc_54097_DS1.pdf
File Type:

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