Details:

Alternative Title:
Diagn Microbiol Infect Dis
Personal Author:
Lockhart, Shawn R. ; Pham, Cau D. ; Kuykendall, Randall J. ; Bolden, Carol B. ; Cleveland, Angela A.
Lockhart, Shawn R. ; Pham, Cau D. ; Kuykendall, Randall J. ; Bolden, Carol B. ; Cleveland, Angela A. Less -
Description:
MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as well as by FKS1 hotspot sequencing. Although C. lusitaniae isolates have MIC values to the echinocandins that are elevated compared to other common species, with regard to known mechanisms of resistance to the echinocandins, isolates with MIC values at or below the epidemiological cutoff values of 0.5 and 1 μg/mL for micafungin and anidulafungin, respectively, should be considered wild type.
Subject:
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Antifungal Agents Article Candida Candida Lusitaniae Drug Resistance, Fungal Echinocandin Echinocandins Epidemiological Cutoff Value FKS Glucosyltransferases Humans Microbial Sensitivity Tests Sequence Analysis, DNA
Source:
Diagn Microbiol Infect Dis. 84(1):52-54.
Pubmed ID:
26429293
Pubmed Central ID:
PMC5939560
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:279616bf486e1cc4b8d5f99caaf2246211072b02899253fab7536264829242fe
Download URL:
https://stacks.cdc.gov/view/cdc/53831/cdc_53831_DS1.pdf
File Type:

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