A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease

Wormser, Gary P.; Strle, Franc; Shapiro, Eugene D.; Dattwyler, Raymond J.; Auwaerter, Paul G.

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A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease

Published Date:

Nov 12 2016

Source:

Diagn Microbiol Infect Dis. 87(2):163-167.

[PDF-72.61 KB]

Details:

Personal Authors:

Wormser, Gary P. ; Strle, Franc ; Shapiro, Eugene D. ; Dattwyler, Raymond J. ; Auwaerter, Paul G. ;

Keywords:

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Pubmed ID:

27914746

Pubmed Central ID:

PMC5924701

Description:

In older studies, a chronic distal symmetric sensory neuropathy was reported as a relatively common manifestation of late Lyme disease in the United States. However, the original papers describing this entity had notable inconsistencies and certain inexplicable findings, such as reports that this condition developed in patients despite prior antibiotic treatment known to be highly effective for other manifestations of Lyme disease. More recent literature suggests that this entity is seen rarely, if at all. A chronic distal symmetric sensory neuropathy as a manifestation of late Lyme disease in North America should be regarded as controversial and in need of rigorous validation studies before acceptance as a documented clinical entity.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

R01 CK000152/CK/NCEZID CDC HHS/United States
KL2 TR000140/TR/NCATS NIH HHS/United States
UL1 TR000142/TR/NCATS NIH HHS/United States
R43 AI122399/AI/NIAID NIH HHS/United States
KL2 TR001862/TR/NCATS NIH HHS/United States
R43 AI120364/AI/NIAID NIH HHS/United States
R44 AI102435/AI/NIAID NIH HHS/United States

Main Document Checksum:

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Supporting Files:

nihms961244.nxml

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