Prenatal and Early Life Triclosan and Parabens Exposure and Allergic Outcomes

Details

• Alternative Title:
  J Allergy Clin Immunol
• Personal Author:
  Lee-Sarwar, Kathleen ; Hauser, Russ ; Calafat, Antonia M. ; Ye, Xiaoyun ; O’Connor, George T. ; Sandel, Megan ; Bacharier, Leonard B. ; Zeiger, Robert S. ; Laranjo, Nancy ; Gold, Diane R. ; Weiss, Scott T. ; Litonjua, Augusto A. ; Savage, Jessica H.
• Description:
  Background
  
  In cross-sectional studies, triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease.
  
  Objectives
  
  We investigated the association between prenatal and early life triclosan and parabens exposure and childhood allergic disease in a prospective, longitudinal study.
  
  Methods
  
  Subjects were enrollees in VDAART, the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben and propyl paraben concentrations were quantified in maternal plasma samples pooled from first and third trimesters and urine samples from children at age 3 or 4 years. Outcomes were parental report of physician-diagnosed asthma or recurrent wheezing, and allergic sensitization to food or environmental antigens based on serum specific IgE levels at age 3 in high-risk children.
  
  Results
  
  Analysis included 467 mother-child pairs. Overall, there were no statistically significant associations of maternal plasma or child urine triclosan or parabens concentrations with asthma or recurrent wheeze, food or environmental sensitization at age 3. A trend toward an inverse association between triclosan and parabens exposure and allergic sensitization was observed. There was evidence of effect measure modification by sex, with higher odds of environmental sensitization associated with increasing concentrations of parabens in males compared to females.
  
  Conclusions
  
  We did not identify a consistent association between prenatal and early life triclosan or parabens concentrations and childhood asthma, recurrent wheeze or allergic sensitization in the overall study population. The differential effects of triclosan or parabens exposure on allergic sensitization by sex observed in this study warrants further exploration.
  
  
• Subjects:
  Article Child, Preschool Cross-Sectional Studies Female Humans Hypersensitivity Longitudinal Studies Male Paraben Parabens Pregnancy Prenatal Exposure Delayed Effects Prenatal Sensitization Asthma Prospective Studies Randomized Controlled Trials As Topic Triclosan

  More +
• Source:
  J Allergy Clin Immunol. 142(1):269-278.e15
• Pubmed ID:
  29111213
• Pubmed Central ID:
  PMC5924494
• Document Type:
  Journal Article
• Funding:
  U01 HL091528/HL/NHLBI NIH HHS/United States ; T32 AI007306/AI/NIAID NIH HHS/United States ; K23 AI110522/AI/NIAID NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; T32 HL007427/HL/NHLBI NIH HHS/United States
• Volume:
  142
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:63b15363c60a92ab665fa7a71483c0b4276862629bfdd2e61b417dca991644a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/53690/cdc_53690_DS1.pdf
• File Type:
  [PDF - 912.06 KB ]