Demographic and Clinical Correlates of Seizure Frequency: Findings from the Managing Epilepsy Well Network Database

Details

• Alternative Title:
  J Clin Neurol
• Personal Author:
  Chen, Erdong ; Sajatovic, Martha ; Liu, Hongyan ; Bukach, Ashley ; Tatsuoka, Curtis ; Welter, Elisabeth ; Schmidt, Samantha S. ; Bamps, Yvan A. ; Stoll, Shelley C. ; Spruill, Tanya M. ; Friedman, Daniel ; Begley, Charles E. ; Shegog, Ross ; Fraser, Robert T. ; Johnson, Erica K. ; Jobst, Barbara C.
• Description:
  Background and Purpose
  
  Epilepsy is a chronic neurological disease that represents a tremendous burden on both patients and society in general. Studies have addressed how demographic variables, socioeconomic variables, and psychological comorbidity are related to the quality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on how these factors may differ between patients who exhibit varying degrees of seizure control. This study utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for Disease Control and Prevention with the aim of elucidating differences in demographic variables, depression, and QOL between adult PWE.
  
  Methods
  
  Demographic variables, depression, and QOL were compared between PWE who experience clinically relevant differences in seizure occurrence.
  
  Results
  
  Gender, ethnicity, race, education, income, and relationship status did not differ significantly between the seizure-frequency categories (p>0.05). People with worse seizure control were significantly younger (p=0.039), more depressed (as assessed using the Patient Health Questionnaire) (p=0.036), and had lower QOL (as determined using the 10-item Quality of Life in Epilepsy for Adults scale) (p<0.001).
  
  Conclusions
  
  The present results underscore the importance of early screening, detection, and treatment of depression, since these factors relate to both seizure occurrence and QOL in PWE.
  
  
• Subjects:
  Depression Epilepsy Original Article Quality Of Life Seizure Frequency Self-management
• Source:
  J Clin Neurol. 2018; 14(2):206-211.
• Pubmed ID:
  29504297
• Pubmed Central ID:
  PMC5897204
• Document Type:
  Journal Article
• Funding:
  U48 DP005002/DP/NCCDPHP CDC HHS/United States ; U48 DP005010/DP/NCCDPHP CDC HHS/United States ; U48 DP005042/DP/NCCDPHP CDC HHS/United States ; U48 DP005013/DP/NCCDPHP CDC HHS/United States ; U48 DP001935/DP/NCCDPHP CDC HHS/United States ; U48 DP005008/DP/NCCDPHP CDC HHS/United States ; U48 DP005022/DP/NCCDPHP CDC HHS/United States
• Volume:
  14
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8a3b7e5c4559ee70307989dde472af54f816cd9409ee7c4c70a9094af5784cb7
• Download URL:
  https://stacks.cdc.gov/view/cdc/53659/cdc_53659_DS1.pdf
• File Type:
  [PDF - 848.31 KB ]