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Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy
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April 10 2018
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Source: Ann Neurol. 83(4):858-862
[PDF-161.70 KB]
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Alternative Title:Ann Neurol
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Description:We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE| ). We analyze PTE| risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE| (odds ratio [OR], 3.16 [0.99, 11.68]); subdural hematoma is another independent risk factor (OR, 4.13 [1.18, 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest that increased EA prevalence identifies patients at increased risk for PTE| , and that EAs acutely post-TBI can identify patients most likely to benefit from antiepileptogenesis drug trials. Ann Neurol 2018;83:858-862.
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Pubmed ID:29537656
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Pubmed Central ID:PMC5912971
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Volume:83
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Issue:4
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