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Defining the sizes of airborne particles that mediate influenza transmission in ferrets
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Feb 20 2018
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Source: Proc Natl Acad Sci U S A. 2018; 115(10):E2386-E2392.
[PDF-1.34 MB]
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Alternative Title:Proc Natl Acad Sci U S A
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Description:Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
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Pubmed ID:29463703
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Pubmed Central ID:PMC5877994
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Volume:115
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Issue:10
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