Defining the sizes of airborne particles that mediate influenza transmission in ferrets

Zhou, Jie; Wei, Jianjian; Choy, Ka-Tim; Sia, Sin Fun; Rowlands, Dewi K.; Yu, Dan; Wu, Chung-Yi; Lindsley, William G.; Cowling, Benjamin J.; McDevitt, James; Peiris, Malik; Li, Yuguo; Yen, Hui-Ling

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Defining the sizes of airborne particles that mediate influenza transmission in ferrets

Published Date:

Feb 20 2018

Source:

Proc Natl Acad Sci U S A. 2018; 115(10):E2386-E2392.

[PDF-1.34 MB]

Details:

Alternative Title:

Proc Natl Acad Sci U S A

Personal Author:

Zhou, Jie ; Wei, Jianjian ; Choy, Ka-Tim ; Sia, Sin Fun ; Rowlands, Dewi K. ; ... More ▼

Description:

Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.

Subject:

[+]

Pubmed ID:

29463703

Pubmed Central ID:

PMC5877994

Document Type:

Journal Article

Funding:

HHSN272201400006C/AI/NIAID NIH HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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