Details:

Alternative Title:
Proc Natl Acad Sci U S A
Personal Author:
Zhou, Jie ; Wei, Jianjian ; Choy, Ka-Tim ; Sia, Sin Fun ; Rowlands, Dewi K. ; ... More +
Zhou, Jie ; Wei, Jianjian ; Choy, Ka-Tim ; Sia, Sin Fun ; Rowlands, Dewi K. ; Yu, Dan ; Wu, Chung-Yi ; Lindsley, William G. ; Cowling, Benjamin J. ; McDevitt, James ; Peiris, Malik ; Li, Yuguo ; Yen, Hui-Ling ; Less -
Description:
Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
Subject:
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Air
Air Microbiology
Animals
Ferrets
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Male
Virus Replication

Source:
Proc Natl Acad Sci U S A. 2018; 115(10):E2386-E2392.
Pubmed ID:
29463703
Pubmed Central ID:
PMC5877994
Document Type:
Journal Article ;
Funding:
HHSN272201400006C/AI/NIAID NIH HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4aae33f57c484007dc2e3af9c70c8b7bb8b7cfffb0851a231a8307704696d836
File Type:

Supporting Files

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