Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Marin, Mona ; Willis, English D. ; Marko, Ann ; Rasmussen, Sonja A. ; Bialek, Stephanie R. ; ... More +
Marin, Mona ; Willis, English D. ; Marko, Ann ; Rasmussen, Sonja A. ; Bialek, Stephanie R. ; Dana, Adrian Less -
Description:
Vaccines that contain live attenuated varicella-zoster virus (VZV) (Varivax, ProQuad, and Zostavax [all products of Merck & Co., Inc.]) are contraindicated during pregnancy. To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or during pregnancy, Merck and CDC established the Merck/CDC Pregnancy Registry for VZV-Containing Vaccines in 1995. This report updates previously published summaries of registry data, provides the rationale for the closure of the registry, and describes plans for continued monitoring of the safety of these vaccines when inadvertently administered to pregnant women or immediately before pregnancy. From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk.
Subjects:
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Female Herpesvirus 3, Human Herpes Zoster Herpes Zoster Vaccine Humans Pregnancy Pregnancy Outcome Registries
Source:
MMWR Morb Mortal Wkly Rep. 2014; 63(33):732-733.
Pubmed ID:
25144545
Pubmed Central ID:
PMC5779435
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:fa8070324e2a07aeed9b3b3c8b52e69b95dca00c41a2055821b3c4fe76c05813
Download URL:
https://stacks.cdc.gov/view/cdc/53335/cdc_53335_DS1.pdf
File Type:

Supporting Files

• 732-733.nxml

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