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Guidance for laboratory biomonitoring programs : developing biomonitoring capabilities
  • Published Date:
    April 2012
  • Language:
    English
Filetype[PDF-932.79 KB]


Details:
  • Description:
    The goals of this guidance are to outline the infrastructure and expertise needed to develop laboratory capacity for a biomonitoring program and to highlight some of the main considerations chemists should address before beginning a biomonitoring study, which include the need to:

    • Define the goals of a biomonitoring study;

    • Choose the appropriate biomarker in the appropriate matrix at a suf cient level of sensitivity;

    • Identify resource needs and sources of potential funding;

    • Collaborate with epidemiologists and toxicologists in the development of the study design and to analyze and communicate biomonitoring data;

    • Produce reliable, valid and comparable data;

    • Engage the community early in the study design process; and

    • Develop an effective communication plan that involves reporting of individual results (if appropriate), aggregate data and access to public health, citizens or medical professionals for results distribution and interpretation.

    While the technology and instrumentation used for biomonitoring testing have a lot in common with environmental testing laboratories, biomonitoring presents a set of unique challenges. Assaying clinical matrices involves the safe handling of potentially infectious materials, different interferences, and possibly the analysis of metabolites. The greatest differences between bio- monitoring and environmental testing involve the interpretation of clinical ndings and effective communication of results on an individual and community basis.

    EH_2012_Guidance-for-Laboratory-Biomonitoring-Programs.pdf

    Running title: Guidance for biomonitoring programs.

    This report was supported 100% by Cooperative Agreement Number #U60/CD303019 from Centers for Disease Con- trol and Prevention (“CDC”). Its contents are solely the responsibility of the authors and do not necessarily represent the of cial views of CDC.

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