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Nitrogen Dioxide Exposure in School Classrooms of Inner-City Children with Asthma
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October 05 2017
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Source: J Allergy Clin Immunol. 141(6):2249-2255.e2
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Details:
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Alternative Title:J Allergy Clin Immunol
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Description:Background
Ambient and home exposure to nitrogen dioxide (NO2) causes asthma symptoms and decreased lung function in children with asthma. Little is known about the health effects of school classroom pollution exposure.
Objective
We aimed to determine the effect of indoor classroom NO2 on lung function and symptoms of inner-city schoolchildren with asthma.
Methods
Children enrolled in the School Inner City Asthma Study were followed for one academic year. Subjects performed spirometry and fractional exhaled nitric oxide (FeNO) twice during the school year, at school. Classroom NO2 was collected by passive sampling for 1 week periods, twice per year coinciding with lung function testing. Generalized estimating equation models assessed lung function and symptom relationships with the temporally nearest classroom NO2 level.
Results
NO2 mean values were 11.1ppb (range 4.3 – 29.7ppb). In total, exposure data was available for 296 subjects; 188 with complete spirometry data. Above a threshold of 8ppb NO2, and after adjusting for race and season (spirometry standardized by age, height, and gender), NO2 was highly associated with airflow obstruction such that each 10ppb rise in NO2 was associated with a 5% decline in FEV1/FVC (β: −0.05, 95% confidence interval (CI) [−0.08, −0.02], p=0.01). FEF25-75% predicted was also inversely associated with higher NO2 exposure (β: −22.8, 95%CI [−36.0, −9.7], p=0.01). There was no significant association of NO2 with FEV1% predicted, FeNO or asthma symptoms. Additionally, there was no effect modification of atopy on lung function or symptom outcomes.
Conclusion
In children with asthma, indoor classroom NO2 may be associated with increased airflow obstruction.
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Source:
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Pubmed ID:28988796
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Pubmed Central ID:PMC5886827
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