Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ma, Mai-Juan ; Liu, Cheng ; Wu, Meng-Na ; Zhao, Teng ; Wang, Guo-Lin ; Yang, Yang ; Gu, Hong-Jing ; Cui, Peng-Wei ; Pang, Yuan-Yuan ; Tan, Ya-Yun ; Hang, Hui ; Lin, Bao ; Qin, Jiang-Chun ; Fang, Li-Qun ; Cao, Wu-Chun ; Cheng, Li-Ling
• Description:
  Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
• Subjects:
  Aged Animals Antibodies, Viral Female History, 21St Century Hospitalization Humans Influenza, Human/Epidemiology Influenza, Human/History Influenza, Human/Immunology Influenza, Human/Virology Influenza A Virus, H7N9 Subtype Male Mice Middle Aged Research Serologic Tests Survivors

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• Source:
  Emerg Infect Dis. 24(4):663-672.
• Pubmed ID:
  29432091
• Pubmed Central ID:
  PMC5875250
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  24
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d3bfdb8a94a28bec4a4bdd65c482dfdcadcc28736a7f3b587e6494b5f120c551
• Download URL:
  https://stacks.cdc.gov/view/cdc/53081/cdc_53081_DS1.pdf
• File Type:
  [PDF - 2.34 MB ]