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Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017
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Apr 17 2018
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Source: Emerg Infect Dis. 24(4):663-672.
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Alternative Title:Emerg Infect Dis
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Description:Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
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Pubmed ID:29432091
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Pubmed Central ID:PMC5875250
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Volume:24
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Issue:4
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