Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Nassan, Feiby L. ; Coull, Brent A. ; Gaskins, Audrey J. ; Williams, Michelle A. ; Skakkebaek, Niels E. ; Ford, Jennifer B. ; Ye, Xiaoyun ; Calafat, Antonia M. ; Braun, Joseph M. ; Hauser, Russ
• Description:
  Background:
  
  Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men’s exposure is understudied.
  
  Objectives:
  
  We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.
  
  Methods:
  
  In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004–2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.
  
  Results:
  
  Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66–156%) and hand/body lotion (79–147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254–1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.
  
  Conclusions:
  
  We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374
  
  
• Subjects:
  Adult Cosmetics Environmental Exposure Hazardous Substances Humans Male Parabens Phthalic Acids Research
• Source:
  Environ Health Perspect. 125(8).
• Pubmed ID:
  28886595
• Pubmed Central ID:
  PMC5783668
• Document Type:
  Journal Article
• Funding:
  P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States
• Volume:
  125
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b230b0abbb751d5c54063f2082a47f131299cb17a37394337e7de86ae12ed2b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/52916/cdc_52916_DS1.pdf
• File Type:
  [PDF - 2.07 MB ]