Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/EHP1374
Personal Author:
Nassan, Feiby L. ; Coull, Brent A. ; Gaskins, Audrey J. ; Williams, Michelle A. ; Skakkebaek, Niels E. ; ... More +
Nassan, Feiby L. ; Coull, Brent A. ; Gaskins, Audrey J. ; Williams, Michelle A. ; Skakkebaek, Niels E. ; Ford, Jennifer B. ; Ye, Xiaoyun ; Calafat, Antonia M. ; Braun, Joseph M. ; Hauser, Russ Less -
Description:
Background:

Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men’s exposure is understudied.

Objectives:

We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men.

Methods:

In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004–2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use.

Results:

Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value<0.01) and deodorant (74%, p-value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66–156%) and hand/body lotion (79–147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254–1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant.

Conclusions:

We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374


Subject:
[+]
Adult
Cosmetics
Environmental Exposure
Hazardous Substances
Humans
Male
Parabens
Phthalic Acids
Research

Source:
Environ Health Perspect. 125(8).
Pubmed ID:
28886595
Pubmed Central ID:
PMC5783668
Document Type:
Journal Article
Funding:
P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States
P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b230b0abbb751d5c54063f2082a47f131299cb17a37394337e7de86ae12ed2b7
File Type:

Supporting Files

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  	EHP1374.s001.acco.pdf	pdf
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