Welcome to CDC stacks | Underdiagnosis of influenza virus infection in hospitalized older adults - 52767 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Underdiagnosis of influenza virus infection in hospitalized older adults
Filetype[PDF-87.58 KB]


Details:
  • Pubmed ID:
    29341100
  • Pubmed Central ID:
    PMC5863754
  • Description:
    Objective

    To describe factors associated with provider-ordered influenza testing among hospitalized adults.

    Design

    Information on patient demographics, symptoms, and provider-ordered influenza testing were collected by questionnaire and chart review. We conducted prospective laboratory-based surveillance using reverse-transcriptase polymerase chain reaction (RT-PCR), the gold-standard for diagnosis of influenza, to determine how patient characteristics and provider-ordered testing impacted accurate influenza diagnosis.

    Setting

    One academic and three community hospitals in Davidson County, Tennessee, USA.

    Participants

    1422 adults ages 18 years and older with acute respiratory illness or non-localizing fever.

    Measurements

    We compared characteristics of participants with and without provider-ordered testing for influenza using the Wilcoxon test and Pearson’s chi-square test. Multivariable logistic regression models identified factors predictive of provider-ordered influenza testing.

    Results

    Overall 28% (399/1422) of participants had provider-ordered influenza testing. Patients who were tested were younger than those not tested (58 ± 18 years vs. 66 ± 15 years, p < 0.001) and more likely to have influenza-like illness (ILI, 71% vs. 49%, p < 0.001). ILI increased with decreasing age: 48% ≥ 65 years; 60% 50–64 years; and 63% 18–49 years. Among all patients, presence of ILI and younger age were independent predictors of provider-ordered testing. Among the 136 patients with RT-PCR confirmed influenza, ILI was the only significant predictor of provider-ordered testing (AOR 3.43, 95% CI 1.22–9.70).

    Conclusion

    Adults 65 years and older hospitalized with fever or respiratory symptoms during influenza season are less likely to have a provider-ordered influenza test than younger adults. Some, but not all, of this disparity is due to a lower likelihood of ILI presentation. Further strategies are needed to increase clinician awareness and testing in this vulnerable group.

  • Document Type:
  • Collection(s):
  • Main Document Checksum:
No Related Documents.
You May Also Like: