THE EFFECTS OF SLEEP AND LIGHT AT NIGHT ON MELATONIN IN ADOLESCENTS

Details

• Alternative Title:
  Hormones (Athens)
• Personal Author:
  Hersh, Caleb ; Sisti, Julia ; Richiutti, Vincent ; Schernhammer, Eva
• Description:
  Objective
  
  The circadian hormone melatonin has wide-reaching effects on human physiology. In adolescents, the impact of nighttime light exposure and other modifiable behavioral factors on melatonin levels is poorly understood.
  
  Design
  
  We cross-sectionally examined the influence of nighttime behaviors on melatonin levels in 100 adolescents (average age: 15.7; 55 female, 45 male), who completed a self-administered questionnaire and provided a first morning urine sample to assay for urinary 6-sulfatoxymelatonin (aMT6s) levels. We used mixed-effects regression models to test for differences in aMT6s levels by categories of covariates.
  
  Results
  
  Self-reported sleep duration, ambient light levels during sleep, and use of electronics after turning off lights did not significantly predict aMT6s levels. Compared to those who reported weekend bedtimes before 11pm, urinary aMT6s levels were significantly lower among participants reporting weekend bedtimes after midnight (52.5 vs. 38.0 ng/mg creatinine, Ptrend=0.007). Sleep interruption also appeared to be significantly associated with lower urinary aMT6s levels, but only if lights were turned on during sleep interruption (43.0 ng/mg creatinine for participants with sleep interruption but not turning lights on, vs. 24.6 ng/mg creatinine for participants reporting that they turned on the light when their sleep was interrupted Pdifference=0.032).
  
  Conclusions
  
  Our study suggests that self-reported sleep-related behaviors have little to no effect on adolescent circadian systems, though larger studies are needed to confirm our findings.
  
  
• Subjects:
  6-sulfatoxymelatonin Adolescent Adolescent Development Adolescents Article Circadian Rhythm Female Humans Light Light At Night Male Melatonin Sleep Sleep Duration

  More +
• Source:
  Hormones (Athens). 14(3):399-409.
• Pubmed ID:
  26233931
• Pubmed Central ID:
  PMC5857294
• Document Type:
  Journal Article
• Funding:
  T32 CA0090001/CA/NCI NIH HHS/United States ; R01 OH009803/OH/NIOSH CDC HHS/United States ; R25 CA098566/CA/NCI NIH HHS/United States ; R01OH009803/OH/NIOSH CDC HHS/United States ; T32 CA009001/CA/NCI NIH HHS/United States
• Volume:
  14
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a89fd2a48bf25538624e71d02243e63209e016ba144290cfc6af9b08168f0b26
• Download URL:
  https://stacks.cdc.gov/view/cdc/52629/cdc_52629_DS1.pdf
• File Type:
  [PDF - 101.66 KB ]