Details:

Alternative Title:
J Autism Dev Disord
Personal Author:
Wiggins, Lisa D. ; Tian, Lin H. ; Levy, Susan E. ; Rice, Catherine ; Lee, Li-Ching ; ... More +
Wiggins, Lisa D. ; Tian, Lin H. ; Levy, Susan E. ; Rice, Catherine ; Lee, Li-Ching ; Schieve, Laura ; Pandey, Juhi ; Daniels, Julie ; Blaskey, Lisa ; Hepburn, Susan ; Landa, Rebecca ; Edmondson-Pretzel, Rebecca ; Thompson, William Less -
Description:
The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
Subject:
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Article
Autism
Autism Spectrum Disorder
Characterization
Phenotypes
Subgroups

Source:
J Autism Dev Disord. 47(11):3634-3645.
Pubmed ID:
28879490
Pubmed Central ID:
PMC5848505
Document Type:
Journal Article
Funding:
U10DD000181/Centers for Disease Control and Prevention/United States ; U10DD000184/Centers for Disease Control and Prevention/United States ; U10 DD000180/DD/NCBDD CDC HHS/United States ; U10 DD000181/DD/NCBDD CDC HHS/United States ; U10DD000498/Centers for Disease Control and Prevention/United States ; ... More +
U10DD000181/Centers for Disease Control and Prevention/United States ; U10DD000184/Centers for Disease Control and Prevention/United States ; U10 DD000180/DD/NCBDD CDC HHS/United States ; U10 DD000181/DD/NCBDD CDC HHS/United States ; U10DD000498/Centers for Disease Control and Prevention/United States ; U10 DD000184/DD/NCBDD CDC HHS/United States ; U10DD000182/Centers for Disease Control and Prevention/United States ; U01 DD001210/DD/NCBDD CDC HHS/United States ; U01 DD000498/DD/NCBDD CDC HHS/United States ; CC999999/Intramural CDC HHS/United States ; U10 DD000182/DD/NCBDD CDC HHS/United States ; U10DD000180/Centers for Disease Control and Prevention/United States ; U10DD000183/Centers for Disease Control and Prevention/United States ; U10 DD000183/DD/NCBDD CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:ff4bc23fe553a92ccd7cb43ed4eb966635feec9db557200aa4d76bcfe4b5a61b
File Type:

Supporting Files

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