Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

Details

• Alternative Title:
  J Autism Dev Disord
• Personal Author:
  Wiggins, Lisa D. ; Tian, Lin H. ; Levy, Susan E. ; Rice, Catherine ; Lee, Li-Ching ; Schieve, Laura ; Pandey, Juhi ; Daniels, Julie ; Blaskey, Lisa ; Hepburn, Susan ; Landa, Rebecca ; Edmondson-Pretzel, Rebecca ; Thompson, William
• Description:
  The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
• Subjects:
  Autism Autism Spectrum Disorder Characterization Phenotypes Subgroups
• Source:
  J Autism Dev Disord. 47(11):3634-3645.
• Pubmed ID:
  28879490
• Pubmed Central ID:
  PMC5848505
• Document Type:
  Journal Article
• Funding:
  U10DD000181/Centers for Disease Control and Prevention/United States ; U10DD000184/Centers for Disease Control and Prevention/United States ; U10 DD000180/DD/NCBDD CDC HHS/United States ; U10 DD000181/DD/NCBDD CDC HHS/United States ; U10DD000498/Centers for Disease Control and Prevention/United States ; U10 DD000184/DD/NCBDD CDC HHS/United States ; U10DD000182/Centers for Disease Control and Prevention/United States ; U01 DD001210/DD/NCBDD CDC HHS/United States ; U01 DD000498/DD/NCBDD CDC HHS/United States ; CC999999/Intramural CDC HHS/United States ; U10 DD000182/DD/NCBDD CDC HHS/United States ; U10DD000180/Centers for Disease Control and Prevention/United States ; U10DD000183/Centers for Disease Control and Prevention/United States ; U10 DD000183/DD/NCBDD CDC HHS/United States
• Volume:
  47
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ff4bc23fe553a92ccd7cb43ed4eb966635feec9db557200aa4d76bcfe4b5a61b
• Download URL:
  https://stacks.cdc.gov/view/cdc/52465/cdc_52465_DS1.pdf
• File Type:
  [PDF - 129.80 KB ]