Seroepidemiology of Toxoplasma in a coastal region of Haiti; Multiplex bead assay detection of immunoglobulin G antibodies that recognize the SAG2A antigen

Priest, J. W.; Moss, D. M.; Arnold, B. F.; Hamlin, K.; Jones, C. C.; Lammie, P. J.

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Seroepidemiology of Toxoplasma in a coastal region of Haiti; Multiplex bead assay detection of immunoglobulin G antibodies that recognize the SAG2A antigen

Published Date:

Feb 2015

Source:

Epidemiol Infect. 143(3):618-630.

[PDF-1.32 MB]

Details:

Personal Authors:

Priest, J. W. ; Moss, D. M. ; Arnold, B. F. ; Hamlin, K. ; Jones, C. C. ; ... More ▼

Keywords:

[+]

Pubmed ID:

25600668

Pubmed Central ID:

PMC5844480

Description:

Toxoplasma gondii is a globally distributed parasitic protozoan that infects most warm-blooded animals. We incorporated a bead coupled with recombinant SAG2A protein into our Neglected Tropical Disease (NTD) multiplex bead assay (MBA) panel and used it to determine Toxoplasma infection rates in two studies in Haiti. In a longitudinal cohort study of children aged 0-11 years, the infection rate varied with age reaching a maximum of 0·131 infections/year in children aged 3 years [95% confidence interval (CI) 0·065-0·204]. The median time to seroconversion was estimated to be 9·7 years (95% CI 7·6-∞). In a cross-sectional, community-wide survey of residents of all ages, we determined an overall seroprevalence of 28·2%. The seroprevalence age curve from the cross-sectional study also suggested that the force of infection varied with age and peaked at 0·057 infections/year (95% CI 0·033-0·080) at age 2·6 years. Integration of the Toxoplasma MBA into NTD surveys may allow for better estimates of the potential burden of congenital toxoplasmosis in underserved regions.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Place as Subject:

Haiti

Supporting Files:

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