Details:

Alternative Title:
Epidemiol Infect
Personal Author:
Priest, J. W.; Moss, D. M.; Arnold, B. F.; Hamlin, K.; Jones, C. C.; ... More +
Priest, J. W.; Moss, D. M.; Arnold, B. F.; Hamlin, K.; Jones, C. C.; Lammie, P. J.; Less -
Description:
Toxoplasma gondii is a globally distributed parasitic protozoan that infects most warm-blooded animals. We incorporated a bead coupled with recombinant SAG2A protein into our Neglected Tropical Disease (NTD) multiplex bead assay (MBA) panel and used it to determine Toxoplasma infection rates in two studies in Haiti. In a longitudinal cohort study of children aged 0-11 years, the infection rate varied with age reaching a maximum of 0·131 infections/year in children aged 3 years [95% confidence interval (CI) 0·065-0·204]. The median time to seroconversion was estimated to be 9·7 years (95% CI 7·6-∞). In a cross-sectional, community-wide survey of residents of all ages, we determined an overall seroprevalence of 28·2%. The seroprevalence age curve from the cross-sectional study also suggested that the force of infection varied with age and peaked at 0·057 infections/year (95% CI 0·033-0·080) at age 2·6 years. Integration of the Toxoplasma MBA into NTD surveys may allow for better estimates of the potential burden of congenital toxoplasmosis in underserved regions.
Subject:
[+]
Age Factors
Animals
Antibodies, Protozoan
Antibody
Antigens, Protozoan
Article
Child
Child, Preschool
Cohort Studies
Cross-Sectional Studies
Female
Humans
Immunoassay
Immunodominant
Immunoglobulin G
Infant
Infant, Newborn
Infection
Longitudinal Studies
Luminex
Male
Microspheres
Protozoan Proteins
Seroepidemiologic Studies
Toxoplasma
Toxoplasmosis

Source:
Epidemiol Infect. 143(3):618-630.;
Pubmed ID:
25600668
Pubmed Central ID:
PMC5844480
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Place as Subject:
Haiti;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:514bc206e31e643dc6410df150cdac5fe053c3673475c5c3b88b93b0ea07c39f
File Type:

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