Management of Fever in Ambulatory HIV-Infected Adults in
Resource-Limited Settings: Prospective Observational Evaluation of a New
Mozambican Guideline

Brentlinger, Paula E.; Silva, Wilson P.; Buene, Manuel; Morais, Luis; Valverde, Emilio; Vermund, Sten H.; Moon, Troy D.

doi:10.1097/QAI.0000000000000304

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Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline

11 01 2014
By Brentlinger, Paula E. ; Silva, Wilson P. ; Buene, Manuel ; ...
http://dx.doi.org/10.1097/QAI.0000000000000304
Source: J Acquir Immune Defic Syndr. 67(3):304-309

[PDF-328.52 KB]

English

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Details:

Alternative Title:

J Acquir Immune Defic Syndr
Personal Author:

Brentlinger, Paula E. ; Silva, Wilson P. ; Buene, Manuel ; Morais, Luis ; Valverde, Emilio ; ... More +

Brentlinger, Paula E. ; Silva, Wilson P. ; Buene, Manuel ; Morais, Luis ; Valverde, Emilio ; Vermund, Sten H. ; Moon, Troy D. Less -
Description:

A new Mozambican guideline for management of fever in HIV-infected adults requires malaria testing and systematic consideration of specific alternative diagnoses (eg, tuberculosis and bacterial infections) in addition to malaria. We conducted a prospective observational study of the guideline's performance. Of 258 HIV-infected subjects with axillary temperature ≥37.5° C or history of fever, 76.0% improved, 13.6% died or were hospitalized, and 10.5% were lost to follow-up. In multivariate analyses, factors associated with adverse outcomes were bacterial blood stream infection, syndromically diagnosed tuberculosis, lower CD4 T-lymphocyte count, no antiretroviral therapy, lower body mass index, lower hemoglobin, and nonprescription of antibiotics.
Subjects:

[+]

Adult AIDS-Related Opportunistic Infections Ambulatory Care Anti-Bacterial Agents Anti-HIV Agents Antiretroviral Therapy, Highly Active Bacterial Infections CD4 Lymphocyte Count Disease Management Female Fever HIV Infections Humans Male Multivariate Analysis Outcome Assessment, Health Care Practice Guidelines As Topic Prospective Studies Risk Factors Viral Load
Keywords:

[+]

Fever Guidelines HIV/AIDS Mozambique Syndromic Diagnosis Validation
Source:

J Acquir Immune Defic Syndr. 67(3):304-309
Pubmed ID:

25314251
Pubmed Central ID:

PMC5844466
Document Type:

Journal Article
Funding:

U2G PS000631/PS/NCHHSTP CDC HHSUnited States/ ; UL1 TR000445/TR/NCATS NIH HHSUnited States/ ; U2GPS000631/PEPFAR/PEPFARUnited States/

U2G PS000631/PS/NCHHSTP CDC HHSUnited States/ ; UL1 TR000445/TR/NCATS NIH HHSUnited States/ ; U2GPS000631/PEPFAR/PEPFARUnited States/ Less -
Volume:

67
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:d389a993150856869309c23bb5f9cad795576f44da7c83f8485649359c16021c
Download URL:

https://stacks.cdc.gov/view/cdc/52415/cdc_52415_DS1.pdf
File Type:

nihms857500.nxml

xml

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