Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2015.07.098
Personal Author:
Jackson, Michael L. ; Jackson, Lisa A. ; Kieke, Burney ; McClure, David ; Gaglani, Manjusha ; ... More +
Jackson, Michael L. ; Jackson, Lisa A. ; Kieke, Burney ; McClure, David ; Gaglani, Manjusha ; Murthy, Kempapura ; Malosh, Ryan ; Monto, Arnold ; Zimmerman, Richard K. ; Foppa, Ivo M. ; Flannery, Brendan ; Thompson, Mark G. Less -
Description:
Background

We estimated the burden of outpatient influenza and cases prevented by vaccination during the 2011/12 and 2012/13 influenza seasons using data from the United States Influenza Vaccine Effectiveness (US Flu VE) Network.

Methods

We defined source populations of persons who could seek care for acute respiratory illness (ARI) at each of the five US Flu VE Network sites. We identified all members of the source population who were tested for influenza during US Flu VE influenza surveillance. Each influenza-positive subject received a sampling weight based on the proportion of source population members who were tested for influenza, stratified by site, age, and other factors. We used the sampling weights to estimate the cumulative incidence of medically attended influenza in the source populations. We estimated cases averted by vaccination using estimates of cumulative incidence, vaccine coverage, and vaccine effectiveness.

Results

Cumulative incidence of medically attended influenza ranged from 0.8% to 2.8% across sites during 2011/12 and from 2.6% to 6.5% during the 2012/13 season. Stratified by age, incidence ranged from 1.2% among adults 50 years of age and older in 2011/12 to 10.9% among children 6 months to 8 years of age in 2012/13. Cases averted by vaccination ranged from 4 to 41 per 1,000 vaccinees, depending on the study site and year.

Conclusions

The incidence of medically attended influenza varies greatly by year and even by geographic region within the same year. The number of cases averted by vaccination varies greatly based on overall incidence and on vaccine coverage.


Subject:
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Adolescent Adult Aged Aged, 80 And Over Article Child Child, Preschool Female Humans Infant Influenza, Human Influenza Vaccines Male Middle Aged Office Visits Topography, Medical Young Adult
Source:
Vaccine. 33(39):5181-5187.
Pubmed ID:
26271827
Pubmed Central ID:
PMC5843472
Document Type:
Journal Article
Funding:
U01 IP000466/IP/NCIRD CDC HHS/United States ; U01 IP000467/IP/NCIRD CDC HHS/United States ; UL1 TR001857/TR/NCATS NIH HHS/United States
U01 IP000466/IP/NCIRD CDC HHS/United States ; U01 IP000467/IP/NCIRD CDC HHS/United States ; UL1 TR001857/TR/NCATS NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9eb1af78983565e75af89391eeefcfb3abf469135220888cf18d2cffe8335cc0
Download URL:
https://stacks.cdc.gov/view/cdc/52408/cdc_52408_DS1.pdf
File Type:

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