Details:

Alternative Title:
Expert Rev Mol Diagn
Personal Author:
Ganova-Raeva, Lilia M ; Khudyakov, Yury E
Ganova-Raeva, Lilia M ; Khudyakov, Yury E Less -
Description:
Mass spectrometry (MS) has found numerous applications in life sciences. It has high accuracy, sensitivity and wide dynamic range in addition to medium- to high-throughput capabilities. These features make MS a superior platform for analysis of various biomolecules including proteins, lipids, nucleic acids and carbohydrates. Until recently, MS was applied for protein detection and characterization. During the last decade, however, MS has successfully been used for molecular diagnostics of microbial and viral infections with the most notable applications being identification of pathogens, genomic sequencing, mutation detection, DNA methylation analysis, tracking of transmissions, and characterization of genetic heterogeneity. These new developments vastly expand the MS application from experimental research to public health and clinical fields. Matching of molecular techniques with specific requirements of the major MS platforms has produced powerful technologies for molecular diagnostics, which will further benefit from coupling with computational tools for extracting clinical information from MS-derived data.
Subject:
[+]
Article
Communicable Diseases
DNA Methylation
DNA Sequencing
Humans
Infectious Disease
Mass Spectrometry
Molecular Diagnostics
Molecular Surveillance
Nucleic Acids
Pathology, Molecular
Sequence Analysis, DNA
Viral Infection
Viral Proteins
Viruses
Mass Spectrometry

Source:
Expert Rev Mol Diagn. 13(4):377-388
Pubmed ID:
23638820
Pubmed Central ID:
PMC5831079
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8c9ed2ce869774e3c6d11842f1aa56bbf33b94a2c4b446b204189fecc14b481d
File Type:

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