NIAID, NIEHS, NHLBI, MCAN Workshop Report: The Indoor Environment and Childhood Asthma: Implications for Home Environmental Intervention in Asthma Prevention and Management

Details

• Alternative Title:
  J Allergy Clin Immunol
• Personal Author:
  Gold, Diane R. ; Adamkiewicz, Gary ; Arshad, Syed Hasan ; Celedón, Juan C. ; Chapman, Martin D. ; Chew, Ginger L. ; Cook, Donald N. ; Custovic, Adnan ; Gehring, Ulrike ; Gern, James E. ; Johnson, Christine C. ; Kennedy, Suzanne ; Koutrakis, Petros ; Leaderer, Brian ; Mitchell, Herman ; Litonjua, Augusto A. ; Mueller, Geoffrey A. ; O’Connor, George T. ; Ownby, Dennis ; Phipatanakul, Wanda ; Persky, Victoria ; Perzanowski, Matthew S. ; Ramsey, Clare D. ; Salo, Päivi M. ; Schwaninger, Julie M. ; Sordillo, Joanne E. ; Spira, Avrum ; Suglia, Shakira F. ; Togias, Alkis ; Zeldin, Darryl C. ; Matsui, Elizabeth C.
• Description:
  Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
• Keywords:
  Air Pollution, Indoor Allergy Animals Asthma Biomedical Research Child Child Health Clinical Trials Consensus Development Conferences, NIH As Topic Drug Industry Environmental Health Environmental Intervention Fund Raising Humans Indoor Allergens National Heart, Lung, And Blood Institute (U.S.) National Institute Of Allergy And Infectious Diseases (U.S.) National Institute Of Environmental Health Sciences (U.S.) Organizations, Nonprofit Pollutants United States

  More +
• Source:
  J Allergy Clin Immunol. 140(4):933-949
• Pubmed ID:
  28502823
• Pubmed Central ID:
  PMC5632590
• Document Type:
  Journal Article
• Funding:
  T42 OH008672/OH/NIOSH CDC HHSUnited States/ ; UL1 TR001863/TR/NCATS NIH HHSUnited States/ ; Z99 AI999999/ImNIH/Intramural NIH HHSUnited States/ ; MR/K002449/2/MRC_/Medical Research CouncilUnited Kingdom/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; G1000758/MRC_/Medical Research CouncilUnited Kingdom/ ; P01 AI089473/AI/NIAID NIH HHSUnited States/ ; P30 ES020957/ES/NIEHS NIH HHSUnited States/
• Volume:
  140
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:086755730fe797097de765e139cbacea5bcb2ee407b548cb8f9fd3b53f4fd0ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/52014/cdc_52014_DS1.pdf
• File Type:
  [PDF - 275.06 KB ]