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Using exposure windows to explore an elusive biomarker: blood manganese
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Nov 20 2015
Source: Int Arch Occup Environ Health. 89(4):679-687.
[PDF-194.51 KB]
Details:
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Alternative Title:Int Arch Occup Environ Health
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Description:Purpose
We sought to understand the time course between exposure to manganese (Mn) and uptake into the blood, to allow a more meaningful interpretation of exposure-biomarker data, and determine the utility of blood as a biomarker of Mn exposure.
Methods
Welder trainees were monitored over the course of a five quarter training program. Each quarter, trainees gave eight blood samples and had personal air monitoring four times. A mixed model was fit to obtain estimates of airborne exposure by welding type (fixed effect), adjusted for subject (random effect). Considering weekends and days absent as zero exposure, estimated exposures were summed over various exposure windows, and related to measured blood manganese (MnB) using a mixed model.
Results
A relationship consistent with zero was found between MnB and modeled one or seven day exposure. After 30 days of preceding exposure, a one mg/m3-days increase in air Mn is associated with a 0.57 ng/mL increase in MnB (95% CI: −0.04, 1.19). Considering a 90 day exposure window and a cumulative exposure window a one mg/m3-days increase in air Mn is associated with a 0.26 (95% CI: 0.005, 0.51) and 0.09 (95% CI: 0.006, 0.17) ng/mL increase in MnB, respectively.
Conclusions
From this analysis, MnB may begin to act as a biomarker of Mn exposure over longer time periods, or at higher levels of exposure. This novel study design allowed investigation of how MnB relates to different time windows of exposure, representing the most robust Mn exposure assessment in the biomarker literature.
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Subject:
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Pubmed ID:26589320
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Pubmed Central ID:PMC4829443
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