Details:

Alternative Title:
Menopause
Personal Author:
Zhang, Katie ; Zeitlian, Gohar ; Adel, Goli ; Santoro, Nanette F ; Pal, Lubna
Zhang, Katie ; Zeitlian, Gohar ; Adel, Goli ; Santoro, Nanette F ; Pal, Lubna Less -
Description:
Objective

We have previously characterized the reproductive hormone profile in infertile women with diminished ovarian reserve (DOR) as being distinct from that seen in age comparable healthy controls. Hypothesizing that DOR reflects accelerated reproductive aging, we herein compare urinary reproductive hormone dynamics between young women with DOR and a population of chronologically older perimenopausal controls.

Methods

In this prospective observational study, urinary levels of pituitary gonadotropins (FSH and LH) and metabolites of estrogen (E1c) and progesterone (Pdg) were assessed in daily morning urine samples collected in a spontaneous menstrual cycle in 8 infertile premenopausal women with DOR and in 11 perimenopausal controls. Areas under the curves (AUC) were calculated for the respective measured hormones, and comparisons were made using Mann-Whitney U test.

Results

Urinary E1c levels were significantly attenuated in premenopausal women with DOR compared to the older perimenopausal cohort. Despite the relatively lower estrogen, a significantly more pronounced LH surge was evident in the younger population. Early follicular FSH was lower in the women with DOR, but luteal urinary Pdg excretion was comparable in the two groups.

Conclusion

Our data suggest distinctions in functioning of the central (hypothalamic-pituitary) and peripheral (ovarian) components of the hypothalamic-pituitary-ovarian axis in premenopausal women with DOR compared to chronologically older perimenopausal controls. Increased hypothalamic-pituitary sensitivity to estrogen positive feedback is suggested in premenopausal women with DOR. Our observations identify DOR as a distinct entity in the paradigm of reproductive senescence.


Subject:
[+]
Adult
Age Factors
Article
Biomarkers
Diminished Ovarian Reserve
E1c
Estrogens
Female
Follicle Stimulating Hormone
Gonadotropins, Pituitary
Humans
Hypothalamo-Hypophyseal System
LH Surge
Luteal Insufficiency
Luteinizing Hormone
Menopause
Middle Aged
Ovary
Pdg
Perimenopause
Pituitary-Adrenal System
Premenopause
Primary Ovarian Insufficiency
Progesterone
Prospective Studies

Source:
Menopause. 18(8):880-885.
Pubmed ID:
21712737
Pubmed Central ID:
PMC5816680
Document Type:
Journal Article
Funding:
K24 HD041978/HD/NICHD NIH HHS/United States ; CD 41978/CD/ODCDC CDC HHS/United States ; K12/PHS HHS/United States
K24 HD041978/HD/NICHD NIH HHS/United States ; CD 41978/CD/ODCDC CDC HHS/United States ; K12/PHS HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:017165e227d99c62f214fad9c694829fd64978326ec208eec06c2ccba62f25de
File Type:

Supporting Files

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