Details:

Alternative Title:
Antimicrob Resist Infect Control
Personal Author:
Aidara-Kane, Awa ; Angulo, Frederick J. ; Conly, John M. ; Minato, Yuki ; Silbergeld, Ellen K. ; ... More +
Aidara-Kane, Awa ; Angulo, Frederick J. ; Conly, John M. ; Minato, Yuki ; Silbergeld, Ellen K. ; McEwen, Scott A. ; Collignon, Peter J. Less -
Corporate Authors:
for the WHO Guideline Development GroupBalkhyHananCollignonPeterConlyJohnFriedmanCindyHollisAidanKariukiSamuelKwakHyo-SunMcEwenScottMoulinGérardNgandjioAntoinetteRollinBernardRossiFláviaWallingaDavid
Description:
Background

Antimicrobial use in food-producing animals selects for antimicrobial resistance that can be transmitted to humans via food or other transmission routes. The World Health Organization (WHO) in 2005 ranked the medical importance of antimicrobials used in humans. In late 2017, to preserve the effectiveness of medically important antimicrobials for humans, WHO released guidelines on use of antimicrobials in food-producing animals that incorporated the latest WHO rankings.

Methods

WHO commissioned systematic reviews and literature reviews, and convened a Guideline Development Group (GDG) of external experts free of unacceptable conflicts-of-interest. The GDG assessed the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, and formulated recommendations using a structured evidence-to-decision approach that considered the balance of benefits and harms, feasibility, resource implications, and impact on equity. The resulting guidelines were peer-reviewed by an independent External Review Group and approved by the WHO Guidelines Review Committee.

Results

These guidelines recommend reductions in the overall use of medically important antimicrobials in food-producing animals, including complete restriction of use of antimicrobials for growth promotion and for disease prevention (i.e., in healthy animals considered at risk of infection). These guidelines also recommend that antimicrobials identified as critically important for humans not be used in food-producing animals for treatment or disease control unless susceptibility testing demonstrates the drug to be the only treatment option.

Conclusions

To preserve the effectiveness of medically important antimicrobials, veterinarians, farmers, regulatory agencies, and all other stakeholders are urged to adopt these recommendations and work towards implementation of these guidelines.


Subjects:
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Agriculture Antimicrobial Resistance Antimicrobial Use Food Safety Guidelines Guidelines Article Health Consequences Zoonoses
Source:
Antimicrob Resist Infect Control. 7.
Pubmed Central ID:
PMC5772708
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dc111548d6c997bc20327b471152c72339b4f8fe74e7daca3155175ac10ac059
Download URL:
https://stacks.cdc.gov/view/cdc/51188/cdc_51188_DS1.pdf
File Type:

Supporting Files

• 13756_2017_Article_294.nxml

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