Changing trends in complications of chronic hepatitis C

Details

• Alternative Title:
  Liver Int
• Personal Author:
  Lu, Mei ; Li, Jia ; Rupp, Loralee B. ; Zhou, Yueren ; Holmberg, Scott D. ; Moorman, Anne C. ; Spradling, Philip R. ; Teshale, Eyasu H. ; Boscarino, Joseph A. ; Daida, Yihe G. ; Schmidt, Mark A. ; Trudeau, Sheri ; Gordon, Stuart C.
• Description:
  Background and Aims
  
  Chronic hepatitis C virus (HCV)-related complications have increased over the past decade.
  
  Methods
  
  We used join-point regression modeling to investigate trends in these complications from 2006–2015, and the impact of demographics on these trends. Using data from the Chronic Hepatitis Cohort Study (CHeCS), we identified points at which the trend significantly changed, and estimated the annual percent change (APC) in rates of cirrhosis, decompensated cirrhosis, and all-cause mortality, adjusted by race, sex, and age.
  
  Results
  
  Among 11,167 adults with chronic HCV infection, prevalence of cirrhosis increased from 20.8% to 27.6% from 2006 to 2015 with adjusted annual percentage change (aAPC) of 1.2 (p<0.01). Although incidence of all-cause mortality increased from 1.8% in 2006 to 2.9% in 2015, a join-point was identified at 2010, with aAPCs of 9.6 before (2006<2010; p<0.01) and −5.2 after (2010≤2015; p<0.01), indicating a decrease in mortality from 2010 and onward. Likewise, although overall prevalence of decompensated cirrhosis increased from 9.3% in 2006 to 10.4% in 2015, this increase was confined to patients 60 or older (aAPC=1.5; p=0.023). Asian American and Black/African American patients demonstrated significantly higher rates of cirrhosis than White patients, while older patients and men demonstrated higher rates of cirrhosis and mortality.
  
  Conclusions
  
  Although cirrhosis and mortality among HCV-infected patients in the US have increased in the past decade, the mortality has decreased in recent years.
  
  
• Subjects:
  Adult Age Distribution Age Factors Black Or African American Cause Of Death Hepatitis C, Chronic Humans Incidence Liver Cirrhosis Middle Aged Prevalence Risk Factors Sex Distribution Sex Factors Time Factors White People

  More +
• Source:
  Liver Int. 38(2):239-247
• Pubmed ID:
  28636782
• Pubmed Central ID:
  PMC5777910
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  38
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:177f7454bb53d6ee30dab61c4d5491b83d29422ffd206e26dc8f0b2039354b58
• Download URL:
  https://stacks.cdc.gov/view/cdc/51112/cdc_51112_DS1.pdf
• File Type:
  [PDF - 294.94 KB ]