Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Cheng, Vincent C.C.; Sridhar, Siddharth; Wong, Shuk-Ching; Wong, Sally C.Y.; Chan, Jasper F.W.; Yip, Cyril C.Y.; Chau, Chi-Hung; Au, Timmy W.K.; Hwang, Yu-Yan; Yau, Carol S.W.; Lo, Janice Y.C.; Lee, Cheuk-Kwong; Yuen, Kwok-Yung

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Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Supporting Files Public Domain

Jan 17 2018
By Cheng, Vincent C.C. ; Sridhar, Siddharth ; Wong, Shuk-Ching ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cheng, Vincent C.C. ; Sridhar, Siddharth ; Wong, Shuk-Ching ; Wong, Sally C.Y. ; Chan, Jasper F.W. ; Yip, Cyril C.Y. ; Chau, Chi-Hung ; Au, Timmy W.K. ; Hwang, Yu-Yan ; Yau, Carol S.W. ; Lo, Janice Y.C. ; Lee, Cheuk-Kwong ; Yuen, Kwok-Yung
Description:

Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted. JEV RNA was detected in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid specimens. The second recipient had leukemia and received platelets after undergoing chemotherapy. This patient was asymptomatic; JEV infection was confirmed in this person by IgM seroconversion. This study illustrates that, consistent with other pathogenic flaviviruses, JEV can be transmitted via blood products. Targeted donor screening and pathogen reduction technologies could be used to prevent transfusion-transmitted JEV infection in highly JEV-endemic areas.
Subjects:

Blood Transfusion Disease Outbreaks Encephalitis, Japanese Encephalitis Virus, Japanese Humans Immunocompromised Host Magnetic Resonance Imaging Male Middle Aged Neuroimaging Phylogeny Polymerase Chain Reaction Research Sequence Analysis, DNA
Source:

Emerg Infect Dis. 24(1):49-57.
Document Type:

Journal Article
Place as Subject:

Hong Kong
Location:

Asia
Volume:

24
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:f08174fe183c8b5b607c0bc7a364dfb941004fb82830e963b52ac1178a3aa44d05f545f36c44dcbc6eaf73ba81e0956962a1d1d350955341e451e95ede43f923
Download URL:

https://stacks.cdc.gov/view/cdc/50957/cdc_50957_DS1.pdf
File Type:

[PDF - 1.64 MB ]

File Language:

English

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