Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission

Details

• Alternative Title:
  J Med Virol
• Personal Author:
  Carter, Tonia C. ; Hebbring, Scott J. ; Liu, Jixia ; Mosley, Jonathan D. ; Shaffer, Christian M. ; Ivacic, Lynn C. ; Kopitzke, Sarah ; Stefanski, Elisha L. ; Strenn, Rob ; Sundaram, Maria E. ; Meece, Jennifer ; Brilliant, Murray H. ; Ferdinands, Jill M. ; Belongia, Edward A.
• Description:
  Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune response genes were evaluated for association with seasonal influenza hospitalization in an adult study population with European ancestry. SNP allele and genotype frequencies were compared between hospitalized influenza patients (cases) and population controls in a case-control study that included a discovery group (26 cases and 993 controls) and two independent, validation groups (1 with 84 cases and 4076 controls; the other with 128 cases and 9187 controls). Cases and controls had similar allele frequencies for variant rs12252 in interferon-inducible transmembrane protein 3 (IFITM3) (P > 0.05), and the study did not replicate the previously reported association of rs12252 with hospitalized influenza. In the discovery group, the preliminary finding of an association with a nonsense polymorphism (rs8072510) within the schlafen family member 13 (SFLN13) gene (P = 0.0099) was not confirmed in either validation group. Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza. No other SNPs showed a statistically significant association with hospitalized influenza. Further research is needed to identify genetic factors involved in host response to seasonal influenza infection and to assess whether rs12252, a low-frequency variant in Europeans, contributes to influenza severity in populations with European ancestry.
• Subjects:
  Adult Aged Article Case-Control Studies Electronic Health Records Female Gene Frequency Genetic Predisposition To Disease Genetic Testing Genetic Variation Genotype Hospitalization Host Susceptibility Humans IFITM3 Influenza Influenza, Human Influenza A Virus, H1N1 Subtype Male Membrane Proteins Middle Aged Pilot Projects Polymorphism, Single Nucleotide Polymorphisms RNA-Binding Proteins Virus

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• Source:
  J Med Virol. 90(3):436-446
• Pubmed ID:
  29053189
• Pubmed Central ID:
  PMC5760323
• Document Type:
  Journal Article
• Funding:
  K22 LM011938/LM/NLM NIH HHS/United States ; UL1 TR000445/TR/NCATS NIH HHS/United States ; UL1 TR000427/TR/NCATS NIH HHS/United States ; U01 HG004603/HG/NHGRI NIH HHS/United States ; UL1 RR025011/RR/NCRR NIH HHS/United States ; 16FTF30130005/American Heart Association-American Stroke Association/United States ; U18 IP000183/IP/NCIRD CDC HHS/United States ; RC2 GM092618/GM/NIGMS NIH HHS/United States ; R01 GM114128/GM/NIGMS NIH HHS/United States ; U01 HG008701/HG/NHGRI NIH HHS/United States
• Volume:
  90
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fb22be3d221e111d87adfaabf2f539b8f2bc700f786376fb3e81636bd1a460fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/50847/cdc_50847_DS1.pdf
• File Type:
  [PDF - 679.20 KB ]