Colorectal Cancer Incidence in Asian Populations in California: Effect of Nativity and Neighborhood-Level Factors

Details

• Alternative Title:
  Am J Gastroenterol
• Personal Author:
  Ladabaum, Uri ; Clarke, Christina A. ; Press, David J. ; Mannalithara, Ajitha ; Myer, Parvathi A. ; Cheng, Iona ; Gomez, Scarlett Lin
• Description:
  OBJECTIVES
  
  Heritable and environmental factors may contribute to differences in colorectal cancer (CRC) incidence across populations. We capitalized on the resources of the California Cancer Registry (CCR) and California’s diverse Asian population to perform a cohort study exploring the relationships between CRC incidence, nativity, and neighborhood-level factors across Asian subgroups.
  
  METHODS
  
  We identified CRC cases in the CCR from 1990 to 2004 and calculated age-adjusted CRC incidence rates for non-Hispanic Whites and US-born vs. foreign-born Asian ethnic subgroups, stratified by neighborhood socioeconomic status (SES) and “ethnic enclave.” Trends were studied with joinpoint analysis.
  
  RESULTS
  
  CRC incidence was lowest among foreign-born South Asians (22.0/100,000; 95% confidence interval (CI): 19.7–24.5/100,000) and highest among foreign-born Japanese (74.6/100,000; 95% CI: 70.1–79.2/100,000). Women in all Asian subgroups except Japanese, and men in all Asian subgroups except Japanese and US-born Chinese, had lower CRC incidence than non-Hispanic Whites. Among Chinese men and Filipino women and men, CRC incidence was lower among foreign-born than US-born persons; the opposite was observed for Japanese women and men. Among non-Hispanic Whites, but not most Asian subgroups, CRC incidence decreased over time. CRC incidence was inversely associated with neighborhood SES among non-Hispanic Whites, and level of ethnic enclave among Asians.
  
  CONCLUSIONS
  
  CRC incidence rates differ substantially across Asian subgroups in California. The significant associations between CRC incidence and nativity and residence in an ethnic enclave suggest a substantial effect of acquired environmental factors. The absence of declines in CRC incidence rates among most Asians during our study period may point to disparities in screening compared with Whites.
  
  
• Subjects:
  Adult Aged Aged, 80 And Over Asian Cohort Studies Colorectal Neoplasms Emigrants And Immigrants Female Humans Incidence Male Middle Aged Models, Statistical Regression Analysis Residence Characteristics Risk Factors SEER Program Social Class White People

  More +
• Source:
  Am J Gastroenterol. 109(4):579-588.
• Pubmed ID:
  24492754
• Pubmed Central ID:
  PMC5746419
• Document Type:
  Journal Article
• Funding:
  HHSN261201000034C/PHS HHS/United States ; U58DP003862-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035C/PC,CA/None/None ; HHSN261201000140C/CA/NCI NIH HHS/United States ; N01 PC035136/PC/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States ; HHSN261201000140C/PHS HHS/United States ; N01PC35136/CA/NCI NIH HHS/United States ; P30 CA124435/CA/NCI NIH HHS/United States ; N01-PC-35136/PC/NCI NIH HHS/United States ; N01 PC035137/PC/NCI NIH HHS/United States
• Place as Subject:
  California ; China ; Japan ; Philippines
• Volume:
  109
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7b8f8b437dde1d511ff6eeb9ae2e12a524b81a7461daa81d5c72f60d42e3d402
• Download URL:
  https://stacks.cdc.gov/view/cdc/50648/cdc_50648_DS1.pdf
• File Type:
  [PDF - 458.36 KB ]